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VOLUME 2 , ISSUE 3 ( July-September, 2017 ) > List of Articles


Intravenous Dexmedetomidine enhances the Duration of Spinal Anesthesia with 0.5% Hyperbaric Bupivacaine in Lower Abdominal Surgeries

Malti Agrawal, Yogesh K Sharma

Citation Information : Agrawal M, Sharma YK. Intravenous Dexmedetomidine enhances the Duration of Spinal Anesthesia with 0.5% Hyperbaric Bupivacaine in Lower Abdominal Surgeries. Int J Adv Integ Med Sci 2017; 2 (3):144-148.

DOI: 10.5005/jp-journals-10050-10094

License: CC BY 3.0

Published Online: 01-12-2017

Copyright Statement:  Copyright © 2017; The Author(s).



Spinal block is a preferred technique for most lower abdominal and lower limb surgeries. Lignocaine had been the local anesthetic of choice for decades in such surgeries. With the advent of adjuvants, now it has become possible to enhance the duration of spinal anesthesia. These adjuvants can be given intravenously or intrathecally. Intravenous clonidine and dexmedetomidine have been used in recent studies as adjuvant in spinal anesthesia with promising results. Dexmedetomidine is a more suitable adjuvant compared with clonidine due to its more selective alpha-2A receptor agonist activity.

Aims and objectives

To evaluate the effect of intravenous dexmedetomidine on spinal anesthesia with 0.5% bupivacaine in lower abdominal surgeries in terms of onset and duration of sensory and motor blockade and sensory regression.

Materials and methods

Sixty patients of American Society of Anesthesiologists grades I and II, 25 to 60 years of age, posted for elective lower abdominal surgeries under spinal anesthesia were included in the study and randomly allocated into computer-generated two groups. Group IV received intrathecal 0.5% bupivacaine heavy and intravenous infusion of dexmedetomidine 1 μg/kg over 20 minutes followed by 0.5 μg/kg/hour till the end of surgery. Patients in group III (control group) received intrathecal 0.5% bupivacaine heavy and intravenous normal saline as placebo.


In groups IV and III, mean duration of analgesia was 209 ± 29.93 and 150.20 ± 3.46 minutes respectively. This increase in duration of analgesia in dexmedetomidine group was statistically significant. The mean duration of motor blockade was 189.48 ± 1.34 and 158.18 ± 3.27 minutes respectively. Injection diclofenac sodium 75 mg intramuscularly was used as rescue analgesic.

How to cite this article

Sharma YK, Agrawal M. Intravenous Dexmedetomidine enhances the Duration of Spinal Anesthesia with 0.5% Hyperbaric Bupivacaine in Lower Abdominal Surgeries. Int J Adv Integ Med Sci 2017;2(3):144-148.

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