Comparison of Clonidine and Dexmedetomidine as an Adjuvant to 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block: A Prospective, Randomized, Double-blind and Controlled Study
Citation Information :
Bafna U, Sapru S, Khandelwal M, Kothari V, Mathur R. Comparison of Clonidine and Dexmedetomidine as an Adjuvant to 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block: A Prospective, Randomized, Double-blind and Controlled Study. J Recent Adv Pain 2015; 1 (2):73-77.
Brachial plexus blockade is the cornerstone of regional anesthesia practice. This study was done to compare clonidine and dexmedetomidine as an adjuvant to 0.5% ropivacaine in supraclavicular brachial plexus block (SCB).
Materials and methods
A prospective, randomized, double-blind study was done in 120 patients of American Society of Anaesthesiologist (ASA) grade I and II undergoing elective upper limb surgery under SCB. Patients were randomized into three groups. Group 1 (n = 40) received 30 ml of 0.5% ropivacaine, group 2 (n = 40) received 30 ml of 0.5% ropivacaine with 2 mg/kg clonidine, and group 3 (n = 40) received 30 ml of 0.5% ropivacaine with 1 mg/kg dexmedetomidine. Onset and recovery time of sensory and motor block, duration of analgesia and quality of block, hemodynamic variables, and level of sedation were studied in the three groups.
Results
Sensory and motor block onset times were shorter in group 3 than in group 1 and 2 (p < 0.0001). Sensory and motor block durations and duration of analgesia were longer in group 3 than in groups 1 and 2 (p < 0.0001). Blood pressure and heart rate were lower in group 3 as compared to groups 1 and 2 (p < 0.0001). The number of patients achieving grade IV quality of block was higher in group 3 as compared to the other groups.
Conclusion
Dexmedetomidine when added in SCB shortened the onset of sensory and motor block and enhances the duration of sensory and motor block and duration of analgesia without significant side effects.
How to cite this article
Bafna U, Sharma G, Sapru S, Khandelwal M, Kothari V, Mathur R. Comparison of Clonidine and Dexmedetomidine as an Adjuvant to 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block: A Prospective, Randomized, Double-blind and Controlled Study. J Recent Adv Pain 2015;1(2):73-77.
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