Hospitalised patients are usually more susceptible for development of infections while the hospitals are turning out to be hideouts for various micro-organisms. Hence, incidence of nosocomial infections is on the rise worldwide, more so in the developing countries. This contributes to significant increase in healthcare costs and an unnecessary as well as unacceptable increase in morbidity and mortality. Patients in the intensive care unit are the most susceptible hosts for development of nosocomial infections due to poor protective airway reflexes, invasive monitors and procedures, lack of immunity as a result of their primary disease process, broad spectrum antibiotic therapy, poor nutrition, etc. Although development of newer antibiotics, proper antibiotic regimen and better detection modalities to control infection are desirable, there are several other means by which one can contain the spread of nosocomial infections. These include physical precautions and education to help contain the health care worker (HCW) from becoming a potential vector for transmission of infective organisms by instituting measures such as hand hygiene, use of personal protective equipment, cleaning and disinfection, appropriate disposal and disinfection of health care wastes among others. ‘Hand and mind hygiene’ practice from the HCW can contain the nosocomial infections to a large extent.