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VOLUME 5 , ISSUE 1 ( January-April, 2019 ) > List of Articles

REVIEW ARTICLE

Can Platelet-rich Plasma Injection Help Avoid Replacement Surgery in Osteoarthritis of the Knee?

Gautam Das, Debjyoti Dutta, Chinmoy Roy, Suspa Das

Keywords : Osteoarthritis of the knee, Platelet-rich plasma, Total replacement of the knee

Citation Information : Das G, Dutta D, Roy C, Das S. Can Platelet-rich Plasma Injection Help Avoid Replacement Surgery in Osteoarthritis of the Knee?. J Recent Adv Pain 2019; 5 (1):13-15.

DOI: 10.5005/jp-journals-10046-0124

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Introduction: Osteoarthritis (OA) of the knee is a chronic degenerative condition where pain is the predominant symptom. The most important reason for replacement surgery in advanced OA of the knee is pain. But pain may persist even after total knee arthroplasty in about 20% situation. Clinicians are searching an easier alternative to knee arthroplasty. Materials and methods: Platelet-rich plasma (PRP) is a new modality of treatment which helps in regeneration and relieves pain. It has been used successfully in injured and degenerated tissues. It has been used successfully in knee OA too. Most studies indicate it as an excellent modality and superior to hyaluronic acid (HA) injection in the knee. Some studies indicate that the combination of PRP and HA is even better than PRP alone. Discussion: Inspired by recent studies on PRP, question is raised on whether PRP injection can help avoid replacement surgery? But unless more studies with PRP are conducted on advanced OA, we cannot comment on this based on the available literature.

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  1. Zhang Y, Jordan JM. Epidemiology of Osteoarthritis. Clin Geriatr Med 2010 Aug;26(3):355–369. DOI: 10.1016/j.cger.2010.03.001.
  2. Pal CP, Singh P, et al. Epidemiology of knee osteoarthritis in India and related factors. Indian J Orthop 2016 Sep;50(5):518–522. DOI: 10.4103/0019-5413.189608.
  3. Murphy SL, Lyden AK, et al. The Association between Pain, Radiographic Severity, and Centrally-mediated Symptoms in Women with Knee Osteoarthritis. Arthritis Care Res (Hoboken) 2011 Nov;63(11):1543–1549. DOI: 10.1002/acr.20583.
  4. Hunter DJ, McDougall JJ, et al. The symptoms of OA and the genesis of pain. Rheum Dis Clin North Am 2008 Aug;34(3):623–643. DOI: 10.1016/j.rdc.2008.05.004.
  5. Hannan MT, Felson DT, et al. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol 2000;27(6):1513–1517.
  6. Lawson EH, Gibbons MM, et al. Appropriateness criteria to assess variations in surgical procedure use in the United States. Arch Surg 2011;146:1433–1440. DOI: 10.1001/archsurg.2011.581.
  7. Zhang W, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthr Cartilage 2008;16:137–162. DOI: 10.1016/j.joca.2007.12.013.
  8. Riddle DL, Jiranek WA, et al. Use of a validated algorithm to judge the appropriateness of total knee arthroplasty in the United States: a multicenter longitudinal cohort study. Arthritis Rheumatol 2014;66:2134–2143. DOI: 10.1002/art.38685.
  9. Escobar A, Quintana JM, et al. Development of explicit criteria for total knee replacement. Int J Technol Assess Health Care 2003;19:57–70. DOI: 10.1017/S0266462303000060.
  10. Beswick AD, Wylde V, et al. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open 2012;2:e000435. DOI: 10.1136/bmjopen-2011-000435.
  11. Lenguerrand E, Wylde V, et al. Trajectories of Pain and Function after Primary Hip and Knee Arthroplasty: The ADAPT Cohort Study. PLoS One 2016;11:e0149306. DOI: 10.1371/journal.pone.0149306.
  12. Halket A, Stratford PW, et al. Using hierarchical linear modeling to explore predictors of pain after total hip and knee arthroplasty as a consequence of osteoarthritis. J Arthroplasty 2010;25:254–262. DOI: 10.1016/j.arth.2009.01.007.
  13. Phillips JR, Hopwood B, et al. The natural history of pain and neuropathic pain after knee replacement: a prospective cohort study of the point prevalence of pain and neuropathic pain to a minimu m three-year follow-up. Bone Joint J 2014;96-B:1227–1233. DOI: 10.1302/0301-620X.96B9.33756.
  14. Scott CE, Howie CR, et al. Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg Br 2010;92-B:1253–1258. DOI: 10.1302/0301-620X.92B9.24394.
  15. Judge A, Cooper C, et al. Patient-reported outcomes one year after primary hip replacement in a European Collaborative Cohort. Arthritis Care Res (Hoboken) 2010 Apr;62(4):480–488. DOI: 10.1002/acr.20038.
  16. Dey S. (2017, Aug 17). Knee implants to cost up to 69% less as government caps prices. Retrieved from http://timesofindia.indiatimes.com/articleshow/60094167.cms?utm_source=contentofinterest&utm_medium=text&utm_campaign=cppst.
  17. Riddle DL, Jiranek WA, et al. Use of a Validated Algorithm to Judge the Appropriateness of Total Knee Arthroplasty in the United States. A Multicenter Longitudinal Cohort Study. Arthritis Rheumatol 2014;66:2134–2143.
  18. Slover J, Zuckerman JD. Increasing use of total knee replacement and revision surgery. JAMA 2012;308:1266–1268. DOI: 10.1001/jama.2012.12644.
  19. Ayhan E, Kesmezacar H, et al. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop 2014 Jul 18;5(3):351–361. DOI: 10.5312/wjo.v5.i3.351.
  20. Oladeji LO, Cook JL. Cooled Radio Frequency Ablation for the Treatment of Osteoarthritis-Related Knee Pain: Evidence, Indications, and Outcomes. J Knee Surg 2019 Jan;32(1):65–71. DOI: 10.1055/s-0038-1675418.
  21. Jamison DE, Cohen SP. Radiofrequency techniques to treat chronic knee pain: a comprehensive review of anatomy, effectiveness, treatment parameters, and patient selection. J Pain Res 2018;11:1879–1888. DOI: 10.2147/JPR.S144633.
  22. Ramaswamy Reddy SH, Reddy R, et al. Stem-cell therapy and platelet-rich plasma in regenerative medicines: A review on pros and cons of the technologies. J Oral Maxillofac Pathol 2018 Sep–Dec;22(3):367–374.
  23. Alsousou J, Ali A, et al. The role of platelet-rich plasma in tissue regeneration. Platelets 2013;24(3):173–182. DOI: 10.3109/09537104.2012.684730.
  24. Boswell SG, Cole BJ, et al. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy 2012;28(3):429–439. DOI: 10.1016/j.arthro.2011.10.018.
  25. Akeda K, An HS, et al. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartil 2006;14(12):1272–1280. DOI: 10.1016/j.joca.2006.05.008.
  26. Pereira RC, Scaranari M, et al. Dual effect of platelet lysate on human articular cartilage: a maintenance of chondrogenic potential and a transient proinflammatory activity followed by an inflammation resolution. Tissue Eng Part A 2013;19(11–12):1476–1488. DOI: 10.1089/ten.tea.2012.0225.
  27. Park SI, Lee HR, et al. Time sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures. Mol Cell Biochem 2012;361(1–2):9–17. DOI: 10.1007/s11010-011-1081-1.
  28. Yang SY, Ahn ST, et al. Platelet supernatant promotes proliferation of auricular chondrocytes and formation of chondrocyte mass. Ann Plast Surg 2000;44(4):405–411. DOI: 10.1097/00000637-200044040-00009.
  29. Spreafico A, Chellini F, et al. Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. J Cell Biochem 2009;108(5):1153–1165. DOI: 10.1002/jcb.22344.
  30. Gaissmaier C, Fritz J, et al. Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures. Biomaterials 2005;26(14):1953–1960. DOI: 10.1016/j.biomaterials.2004.06.031.
  31. Sundman EA, Cole BJ, et al. The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med 2014;42(1):35–41. DOI: 10.1177/0363546513507766.
  32. Hassana AS, El-Shafeya AM, et al. Effectiveness of the intra-articular injection of platelet rich plasma in the treatment of patients with primary knee osteoarthritis. Egyptian Rheumatol 2014;37:119–124.
  33. Louis ML, Magalon J, et al. Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation. Arthroscopy 2018 May;34(5):1530–1540. DOI: 10.1016/j.arthro.2017.11.035.
  34. Cole BJ, Karas V, et al. Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis. Am J Sports Med 2017 Feb;45(2):339–346. DOI: 10.1177/0363546516665809.
  35. Kon E, Mandelbaum B, et al. Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis. Arthroscopy 2011;27:1490–1501. DOI: 10.1016/j.arthro.2011.05.011.
  36. Filardo G, Di Matteo B, et al. Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation: A Randomized Controlled Trial. Am J Sports Med 2015 Jul;43(7):1575–1582. DOI: 10.1177/0363546515582027.
  37. Filardo G, Kon E, et al. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord 2012 Nov 23;13:229. DOI: 10.1186/1471-2474-13-229.
  38. Spaková T, Rosocha J, et al. Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid. Am J Phys Med Rehabil 2012 May;91(5):411–417. DOI: 10.1097/PHM.0b013e3182aab72.
  39. Görmeli G, Görmeli CA, et al. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial. Knee Surg Sports Traumatol Arthrosc 2017 Mar;25(3):958–965. DOI: 10.1007/s00167-015-3705-6.
  40. Lana JF, Weglein A, et al. Randomized controlled trial comparing hyaluronic acid, platelet-rich plasma and the combination of both in the treatment of mild and moderate osteoarthritis of the knee. J Stem Cells Regen Med 2016;12(2):69–78.
  41. Iio K, Furukawa KI, et al. Hyaluronic acid induces the release of growth factors from platelet-rich plasma. Asia Pac J Sports Med Arthrosc Rehabil Technol 2016 Apr;4:27–32. DOI: 10.1016/j.asmart.2016.01.001.
  42. Sánchez M, Anitua E, et al. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol 2008;26:910–913.
  43. Paterson KL, Nicholls M, et al. Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study. BMC Musculoskelet Disord 2016;17:67. DOI: 10.1186/s12891-016-0920-3.
  44. Kon E, Buda R, et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 2010;18(4):472–479. DOI: 10.1007/s00167-009-0940-8.
  45. Guillibert C, Charpin C, et al. Single Injection of High Volume of Autologous Pure PRP Provides a Significant Improvement in Knee Osteoarthritis: A Prospective Routine Care Study. Int J Mol Sci 2019 15;20(6):pii: E1327. DOI: 10.3390/ijms20061327.
  46. Sucuoglu H, Üstünsoy S. The short-term effect of PRP on chronic pain in knee osteoarthritis. Agri 2019 Apr;31(2):63–69. DOI: 10.14744/agri.2019.81489.
  47. Patel S, Dhillon MS, et al. Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Trial. Am J Sports Med 2013;41:356. DOI: 10.1177/0363546512471299.
  48. Meheux CJ, McCulloch PC, et al. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Arthroscopy 2016 Mar;32(3):495–505. DOI: 10.1016/j.arthro.2015.08.005.
  49. Dai WL. Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy 2017 Mar;33(3):659–670. DOI: 10.1016/j.arthro.2016.09.024.
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