Hypertension Journal

Register      Login

VOLUME 2 , ISSUE 4 ( October-December, 2016 ) > List of Articles


Renaissance of Chlorthalidone

Anil Pareek, Mahesh Abhyankar, Suraj Ghag

Citation Information : Pareek A, Abhyankar M, Ghag S. Renaissance of Chlorthalidone. Hypertens J 2016; 2 (4):200-208.

DOI: 10.5005/jp-journals-10043-0056

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2016; The Author(s).


How to cite this article

Pareek A, Abhyankar M, Ghag S. Renaissance of Chlorthalidone. Hypertens J 2016;2(4):200-208.

PDF Share
  1. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens 2014 Jun;32(6):1170-1177.
  2. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 2010 May 26;303(20):2043-2050.
  3. Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004 Jan;22(1):11-19.
  4. Hypertension – a community problem. Am J Med 1972 May;52(5):653-663.
  5. Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment. Diabetol Metab Syndr 2010 Aug 18;2:55.
  6. Chlorthalidone versus hydrochlorothiazide: a tale of tortoises and a hare. Hypertension 2011 Dec;58(6):994-995.
  7. Indian guidelines on hypertension (I.G.H.) – III. 2013. J Assoc Physicians India 2013 Feb;61(Suppl 2):6-36.
  8. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002 Dec 18;288(23):2981-2997.
  9. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991 Jun 26;265(24):3255-3264.
  10. Long-term effects of chlorthalidone versus hydrochlorothiazide on electrocardiographic left ventricular hypertrophy in the multiple risk factor intervention trial. Hypertension 2011 Dec;58(6):1001-1007.
  11. Treatment of hypertension in patients with coronary artery disease: a scientific statement from the American Heart Association, American College of Cardiology, and American Society of Hypertension. J Am Soc Hypertens 2015 Jun;9(6):453-498.
  12. Hypertension: clinical management of primary hypertension in adults. NICE Clinical Guideline 127. London: NICE; 2011. Accessed 2016 Jun 19. Available from: http://guidance.nice.org.uk/CG127.
  13. Atenolol and Chlorthalidone Tablets. Accessed 2016 Jun 20. Available from: https://www.drugs.com/pro/atenolol-and-chlorthalidone-tablets.html.
  14. Chlorthalidone – a renaissance in use? Expert Opin Pharmacother 2009 Sep;10(13):2037-2039.
  15. A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone (6.25 mg) combination with losartan-hydrochlorothiazide (12.5 mg) combination in Indian patients with mild-to-moderate essential hypertension. Expert Opin Pharmacother 2009 Jul;10(10):1529-1536.
  16. Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 2004 Jan;43(1):4-9.
  17. Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension 2006 Mar;47(3):352-358.
  18. Efficacy of low-dose chlorthalidone and hydro-chlorothiazide as assessed by 24-h ambulatory blood pressure monitoring. J Am Coll Cardiol 2016 Feb 2;67(4):379-389.
  19. Thiazide diuretics in the management of hypertension. Can J Clin Pharmacol 2004 Spring;11(1):e41-e44.
  20. Mechanism of direct vasodilator effect of thiazide diuretics. Ind J Pharmacol 1981;13(4): 349-351.
  21. Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to Rho kinase. Hypertension 2005 Feb;45(2):233-239.
  22. Heart Disease: a textbook of cardiovascular medicine. 5th ed, W.B. Saunders 1997.
  23. Chlorthalidone alters the vascular reactivity of DOC-salt hypertensive rats to norepinephrine. Braz J Med Biol Res 1990;23(10):999-1003.
  24. Treatment of mild hypertension study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA 1993 Aug 11;270(6):713-724.
  25. Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA 2011 Dec 21;306(23):2588-2593.
  26. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 2015 Nov 26;373(22):2103-2116.
  27. Diabetes Care 2015;38(Suppl1):S5-S7.
  28. Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Diabetes Care 2008 Feb;31(2):353-360.
  29. Clinical effectiveness of low-dose chlorthalidone (6.25 mg) + atenolol combination in stage I hypertensive patients: a multicenter, randomized, controlled study. Curr Med Res Opin 2008 Jun;24(6):1771-1779.
  30. Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in Indian patients with mild-to-moderate essential hypertension. Eur J Med Res 2009 Jul 22;14(7): 297-303.
  31. Changes in serum potassium mediate thiazide-induced diabetes. Hypertension 2008 Dec;52(6):1022-1029.
  32. Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med 2006 Nov 13;166(20):2191-2201.
  33. Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes. Am J Cardiol 2005;95:29-35.
  34. Long-term effects on incident diabetes mellitus on cardiovascular outcomes in people treated for hypertension. The ALLHAT diabetes extension study. Circ Cardiovasc Qual Outcomes 2012;5:153-162.
  35. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA 2011;305:2556-2564.
  36. Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults Secondary Analysis of a Randomized Clinical Trial. JAMA Intern Med. doi:10.1001/jamainternmed.2016.6821.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.