Journal of Research in Ayurvedic Sciences

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VOLUME 4 , ISSUE 4 ( October-December, 2020 ) > List of Articles

Original Article

Efficacy of Ayurveda Interventions in Parkinson's Disease: A Protocol for Systematic Review

E Remya, Akashlal Maneeri, Parvathy G Nair, KM Pratap Shankar

Citation Information : Remya E, Maneeri A, Nair PG, Shankar KP. Efficacy of Ayurveda Interventions in Parkinson's Disease: A Protocol for Systematic Review. J Res Ayurvedic Sci 2020; 4 (4):135-138.

DOI: 10.5005/jras-10064-0114

License: CC BY-NC 4.0

Published Online: 01-12-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Introduction: Parkinson's disease (PD) is the most common form of a group of progressive neurodegenerative disorders characterized by motor, autonomic, and cognitive disturbances. The prevalence of PD is increasing with age and it affects 1% of the population above 60 years. In light of the demand for alternative measures to control PD, a systematic review is being planned to generate evidence for the efficacy, effectiveness, and safety profile of Ayurvedic interventions in the management of PD. Objectives: The primary objective of the present study is the systematic review of published clinical data in view of the safety, efficacy, and effectiveness of Ayurvedic interventions in the management of PD. Materials and methods: Electronic searches from various online databases and clinical trial registries will be done. A manual search for gray literature will also be done from various sources, e.g., printed journals, conference proceedings, colleges, university libraries, etc. Studies published in the English and Hindi language till March 2019 will be sought. Types of study include randomized controlled trials (RCTs), quasi-experimental trials, single group clinical trials, comparative clinical trials (CCTs), pragmatic trials, and review papers on Ayurvedic management of PD or Kampavata. Three investigators shall independently screen all citations and abstracts identified by a primary comprehensive search to sort out potentially eligible trials and eligible trials will be independently evaluated for inclusion in the review based on the inclusion criteria. Data extraction forms for individual study including methods, participants, intervention, comparator, and the outcome shall be prepared. Each of the included trials will be assessed for risk of bias. Primary data analysis will be done for both qualitative and quantitative data. Heterogeneity among trials will be assessed by inspecting forest plots. If heterogeneity is detected, and it is still considered clinically meaningful to combine studies, a random-effects model will be used. A sensitivity analysis, to investigate the robustness of the results to the quality components will be done, provided there are sufficient trials. A funnel plot will be utilized to indicate publication bias, heterogeneity of results, or differences in the methodological quality. Dissemination: The systematic review will be published in a peer-reviewed journal. It will also be disseminated electronically and via print. The review may guide healthcare practices and policy-framing in the treatment of PD with Ayurvedic interventions. Trial registration number: PROSPERO 2019: CRD42019131920 Dated 20/12/2019.

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  1. Parkinson's disease and other extra-pyramidal movement disorders. Harrison's Principles of Internal Medicine, vol. 2, ch. 366 17th ed., The McGraw-Hill Companies, p. 2549.
  2. Parkinson's Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care. London: Royal College of Physicians (UK); 2006. (NICE Clinical Guidelines, No. 35.) 9, Non-motor features of Parkinson's disease. Available from:
  3. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON collaborative study. European community concerted action on the epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;62(1):10–15. DOI: 10.1136/jnnp.62.1.10.
  4. Medical management of levodopa-associated motor complications in patients with Parkinson's disease. CNS Drugs 2007;21(8):677–692. DOI: 10.2165/00023210-200721080-00005.
  5. Samhita C. Vidyotini Hindi Commentary Part I Sutrasthana, chapter 20/11 Reprinted ed., Varanasi: Pub: Bharathi Academy; 2001. p. 399.
  6. Aeitology - symptomatology and treatment of vatic disorders. Chaukhamba Orientalia. 1st ed., 2014. p. 149.
  8. A protocol for systematic review on Ayurvedic interventions in irondeficiency anemia. J Res Ayurvedic Sci 2019;3(2):60–63. DOI: 10.5005/jras-10064-0076.
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