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VOLUME 3 , ISSUE 2 ( May-August, 2017 ) > List of Articles

ORIGINAL ARTICLE

Comparison of Analgesic Effects of Intravenous Nalbuphine and Pentazocine in Patients posted for Short-duration Surgeries: A Prospective Randomized Double-blinded Study

VY Apte, MA Lokapur, RP Sancheiti, KV Kelkar, Pradnya M Bhalerao

Citation Information : Apte V, Lokapur M, Sancheiti R, Kelkar K, Bhalerao PM. Comparison of Analgesic Effects of Intravenous Nalbuphine and Pentazocine in Patients posted for Short-duration Surgeries: A Prospective Randomized Double-blinded Study. J Recent Adv Pain 2017; 3 (2):77-80.

DOI: 10.5005/jp-journals-10046-0073

License: CC BY 3.0

Published Online: 01-12-2015

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Background and objectives

Postoperative pain influences the long-term outcome of the patient in a big way. We performed a randomized prospective double-blind study to evaluate the effects of intravenous (IV) nalbuphine and compared it with IV pentazocine. The primary objective was to compare the duration of analgesia of IV nalbuphine and IV pentazocine and the secondary objective was to study the side-effect profile.

Materials and methods

Sixty American Society of Anesthe­siologists (ASA) physical status I and II patients undergoing short-duration surgery under general anesthesia were randomly allocated in two groups of 30 each to receive either nalbuphine (group I) or pentazocine (group II) IV. The duration of postoperative analgesia, need for rescue analgesia, and side effects if any were monitored. Two-sample t-tests were used to investigate and model the impact of various parameters like duration of analgesia and side-effect profile.

Results

Duration of analgesia in group I (7.43 ± 1.63 hours) was significantly prolonged as compared with group II (4.73 ± 1.62 hours). Statistical significance (p < 0.05) was noted. Significance was not noted between the two groups when sedation score was compared.

Conclusion

Intravenous nalbuphine is superior to IV pentazocine in providing analgesia and causes less sedation.

How to cite this article

Apte VY, Bhalerao PM, Lokapur MA, Sancheiti RP, Kelkar KV. Comparison of Analgesic Effects of Intravenous Nalbuphine and Pentazocine in Patients posted for Short-duration Surgeries: A Prospective Randomized Double-blinded Study. J Recent Adv Pain 2017;3(2):77-80.


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