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VOLUME 2 , ISSUE 2 ( May-August, 2016 ) > List of Articles


A Prospective Randomized and Double-blind Study to evaluate the Efficacy of Magnesium Sulfate on Postoperative Analgesic Requirement in Patients undergoing Laparoscopic Cholecystectomy

Ashutosh Singh, Hariom Khandelwal, Anoop Negi, Bhaskar Dutta

Citation Information : Singh A, Khandelwal H, Negi A, Dutta B. A Prospective Randomized and Double-blind Study to evaluate the Efficacy of Magnesium Sulfate on Postoperative Analgesic Requirement in Patients undergoing Laparoscopic Cholecystectomy. J Recent Adv Pain 2016; 2 (2):49-53.

DOI: 10.5005/jp-journals-10046-0039

Published Online: 01-09-2014

Copyright Statement:  Copyright © 2016; The Author(s).


Background and aims

Magnesium sulfate has recently gained popularity as an adjuvant to general anesthesia. It acts as a blocker of N-methyl D-aspartate (NMDA) antagonist and hence may have a potential role in the prevention of postoperative pain. The aim of the present prospective, randomized, double-blind, and placebocontrolled study was to evaluate the efficacy of injection magnesium sulfate 50 mg/kg as premedication upon postoperative pain and analgesic requirement in patients undergoing elective laparoscopic cholecystectomy under general anesthesia.

Materials and methods

After obtaining institutional ethical committee approval, 100 patients of American Society of Anesthesiologists (ASA) grade 1 and 2 undergoing laparoscopic cholecystectomy under general anesthesia were randomly allocated into two groups to receive either 50 mg/kg magnesium sulfate in normal saline to a total volume of 5 mL (group M, n = 50) or 5 mL of normal saline (group S, n = 50) as premedication prior to general anesthesia. The patients were continuously monitored for postoperative pain using visual analog scale (VAS) in the immediate postoperative period and subsequently at 2-hour intervals for the next 24 hours. Injection tramadol 1 mg/kg was given as the rescue analgesic (VAS ≥ 4).


Both the groups were comparable with respect to demographic variables. There was no statistically significant difference in the postoperative VAS scores (p = 0.489) and tramadol requirement among the groups (p = 0.38).


Magnesium sulfate 50 mg/kg premedication is ineffective in reducing postoperative pain and analgesic requirement in patients undergoing laparoscopic cholecystectomy under general anesthesia.

How to cite this article

Singh A, Khandelwal H, Negi A, Dutta B, Rani P. A Prospective Randomized and Double-blind Study to evaluate the Efficacy of Magnesium Sulfate on Postoperative Analgesic Requirement in Patients undergoing Laparoscopic Cholecystectomy. J Recent Adv Pain 2016;2(2):49-53.

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