Journal on Recent Advances in Pain

Register      Login

VOLUME 2 , ISSUE 1 ( January-April, 2016 ) > List of Articles


Neuropathic Pain and Depression: A Prospective Study to find out Any Association

Emmanuell Q Villano, Sripurna Mandal

Citation Information : Villano EQ, Mandal S. Neuropathic Pain and Depression: A Prospective Study to find out Any Association. J Recent Adv Pain 2016; 2 (1):6-10.

DOI: 10.5005/jp-journals-10046-0026

Published Online: 01-06-2014

Copyright Statement:  Copyright © 2016; The Author(s).



The effect of duration, severity, response to treatment, family and social interactions with chronic pain and depression have been studied extensively. But, none of the studies have ever reported any association of the character of chronic pain particularly neuropathic pain with depression. The aim of this study is to find out the association of neuropathic pain (using painDETECT tool) and depression [using the patient health questionnaire (PHQ-9) scale].

Materials and methods

A prospective analysis of 250 patients, aged 18 to 65 years of either sex suffering from chronic pain for more than 3 months’ duration with an average pain score of 4/10 or more on numerical rating scale (NRS) and moderate to severe depression diagnosed using PHQ-9 scale, were included in the study. Neuropathic character of pain was diagnosed using painDETECT tool. We analyzed the possible association of neuropathic pain with depression.


In 3.2% of patients were found to be suffering from neuropathic pain, 19.6% patients were non-neuropathic or nociceptive pain and 77.2% patients were suffering from mixed type of pain where neuropathic pain may be present. The average depression score on PHQ-9 scale was 14.58 ± 3.72. In 58.4% of patients the depression was moderate, 30.4% of patients the depression was moderately severe and 11.2 % of patients were suffering from severe depression. On analysis of data, we have found that there is no statistically significant association between neuropathic pain and depression (p = 0.8).


We did not find any statistically significant correlation between neuropathic pain and depression.

How to cite this article

Sharma K, Das G, Dey S, Villano EQ, Mandal S. Neuropathic Pain and Depression: A Prospective Study to find out Any Association. J Recent Adv Pain 2016;2(1):6-10.

PDF Share
  1. (access: 08.03.2016).
  2. The relation between multiple pains and mental disorder: results from the World Mental Health Surveys. Pain 2008 Mar;135(1-2):82-91.
  3. Chronic pain and depression: an online survey on Indian experiences. Ind J Pain 2014;28:166-172.
  4. Persistent pain and well-being: a World Health Organization study in primary care. JAMA 1998 Jul 8;280(2):147-151.
  5. Chronic pain: a population-based study. Isr Med Assoc J 2008 Oct;10(10):676-680.
  6. Prevalence of chronic pain benign pain disorder among adults: a review of literature. Pain 1998;77:231-239.
  7. Mental disorders among persons with chronic back and neck pain: results from the World Mental Surverys. Pain 2007;129:332-342.
  8. Pain as a symptom in depressive disorders—II: relationship to personality traits as assessed by means of KSP. Pain 1983;17(4):377-384.
  9. Frequency of painful physical symptoms with major depressive disorder in Asia: relationship with disease severity and quality of life. J Clin Psychiatry 2009;70(1):83-91.
  10. Pain as a symptom of depression: prevalence and clinical correlates in patients attending psychiatric clinics. J Affect Disor 2011;130(1-2):106-112.
  11. A cross-national study of the course of persistent pain in primary care. Pain 2001;92(1-2):195-200.
  12. Depression as a risk factor for onset of an episode of troublesome neck and low back pain. Pain 2004;107(1-2):134-139.
  13. Depression and pain comorbidity: a literature review. Arch Int Med 2003;163(20):2433-2445.
  14. Prevalence and impact of depression and pain in neurology outpatients. J Neurol Neurosurg Psychiatr 2003;74(11):1587-1589.
  15. The temporal relation between pain and depression: results from the longitudinal aging study Amsterdam. Psychosomatic Med 2012;74(9):945-951.
  16. Neuroimaging of pain: insights into normal and pathological pain mechanisms. Neurosci Lett 2012;520(2):129-130.
  17. Human brain mechanisms of pain perception and regulation in health and disease. Euro J Pain 2005;9(4):463-484.
  18. The pain matrix: reloaded or reborn as we image tonic pain using arterial spin labelling. Pain 2010;148(3):359-360.
  19. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci 2013;14(7):502-511.
  20. Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci 2012;15(8):1117-1119.
  21. An overview of Indian research in depression. Ind J Psychiatry 2010;52:S178-8814.
  22. Chronic pain-associated depression: antecedent or consequence of chronic pain? A review. Clin J Pain 1997;13(2):116-137.
  23. Impact of pain on the course of depressive and anxiety disorders. Pain 2012;153(2):429-436.
  24. Impact of pain on depression treatment response in primary care. Psychosomatic Med 2004;66(1):17-22.
  25. Clinical aspects of depression in chronic pain patients. Clin J Pain 1991;7(2):79-94.
  26. Chronic pain and major depressive disorder in the general population. J Psychiatric Res 2010;44(7):454-461.
  27. Classification of chronic pain. 2nd ed. Seattle: IASP Press; 1994. p. 1.
  28. PainDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 2006;22(10):1911-1920.
  29. Pain: Clinical manual for nursing practice. St Louis, MO: Mosby; 1989.
  30. The PHQ-9: validity of a brief depression severity measure. JGIM 2001;16:606-616.
  31. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci 2007;10(9):1116-1124.
  32. The brain reward circuitry in mood disorders. Nat Rev Neurosci 2013;14(9):609-625.
  33. Functional reorganization of the default mode network across chronic pain conditions. PLoS ONE 2014;9(9).
  34. Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis. Brain 2012;135(5):1498-1507.
  35. Psychiatry in chronic pain: a review and update. Curr Psychiatry Rep 2005;7:213-219.
  36. Common chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disorders. J Pain 2008;9:883-891.
  37. Major depressive disorder in the older adult: implications for women. J Women Aging 2007;19:63-77.
  38. Women and major depressive disorder: clinical perspectives on causal pathways. J Womens Health (Larchmt) 2008;17:1583-1590.
  39. Sex, gender and pain: men are from mars, women are from venus. Anesth Analg 2008;107:4-5.
  40. Depression in women. Metabolism 2005;54:49-52.
  41. Predictors of depression in a sample of 1,021 primary care patients with osteoarthritis. Arthritis Rheum 2007;57:415-422.
  42. Major depressive disorder in Latin America: the relationship between depression severity, painful somatic symptoms, and quality of life. J Affect Disord 2005;86:93-98.
  43. Neuroplasticity underlying the comorbidity of pain and depression. Neural Plast 2015;2015:504691.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.