Opioids and the treatment of chronic pain: controversies, current status, and future directions. Exp Clin Psychopharmacol 2008;16:405-416.
Analgesia up to the twentieth century. In: Parnham Bruinvels, MJ, editors. Discoveries in Pharmacology. Psycho and Neuropharmacology. Elsevier: Amsterdam; 1983. p. 357-377.
Autoradiograhic localization of the opiate receptor in rat brain. Life Sci 1975;16:1849-1853.
Identification of opiate receptor binding in intact animals. Life Sci 1975;16:1623-1634.
Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 1975 Dec 18;258(5536):577-580.
Structure of the deltaopioid receptor bound to naltrindole. Nature 2012 May 16;485(7398):400-404.
Crystal structure of the microopioid receptor bound to a morphinan antagonist. Nature 2012;485(7398):321-326.
A potent and selective endogenous agonist for the mu-opiate receptor. Nature 1997 Apr 3;386(6624):499-502.
Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 1997;18:1635-1639.
Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs. Med Res Rev 2012 May;32(3):536-580.
Detection and function of opioid receptors on cells from the immune system. Clin Diagn Lab Immunol 2000;7:719-723.
Evidence for opioid receptors on cells involved in host defense and the immune system. J Neuroimmunol 1998;83:45-56.
The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis. Proc Soc Exp Biol Med 1996;213(3):248-257.
Opioid receptors in the gastrointestinal tract. Regul Pept 2009;155:11-326.17.
The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res 1995;700:89-98.
Oligomerization of opioid receptors: generation of novel signaling units. Curr Opin Pharmacol 2002;2:76-81.
Evidence that opioids may have tolllike receptor 4 and MD2 effects. Brain Behav Immun 2010;24:83-95.
Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed mu agonist/ delta antagonist opioid analgesic with reduced tolerance liabilities. ACS Chem Neurosci 2013;4:1256-1266.
Modulation of gastrointestinal function by MuDelta, a mixed micro opioid receptor agonist/micro opioid receptor antagonist. Br J Pharmacol 2012 Nov;167(5):1111-1125.
Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study. Gastroenterology 2013;145(2):329-338.