Citation Information :
Anitharaj V, Gunasekaran D, Pradeep J, Stephen S. Gastrointestinal Manifestations of Scrub Typhus in Children and Adults from Puducherry and Neighboring Tamil Nadu State, India. J Gastrointest Infect 2017; 7 (1):1-4.
Scrub typhus (ST) is reported from almost every Indian state. In our tertiary care teaching hospital at Puducherry, we looked for gastrointestinal (GI) manifestations of ST in children as well as adults and correlated with laboratory findings. We examined 588 serum samples for immunoglobulin M (IgM) antibody against Orientia tsutsugamushi by enzyme-linked immunosorbent assay (ELISA) and observed that 335 (56.97%) of these clinically suspected ST patients were positive, comprising 134 children and 201 adults. Statistically significant (p ≤ 0.05) number of adults had nausea (p = 0.000) and abdominal pain (p = 0.020) than children. Similar trend was observed in adults with reference to increased liver enzymes (aspartate aminotransferase/ alanine aminotransferase/alkaline phosphatase; p = 0.000), creatinine (>1.0 mg/dL; p = 0.007), and platelet count (≤1.5 lakhs/mm3; p = 0.026). Rash in children is the only statistically significant manifestation than adults (p = 0.03). More number of children were positive than adults, but without any statistical significance, with reference to other parameters like cough/expectoration (p = 0.735), hepatomegaly (p = 0.730), and eschar (p = 0.721).
Varghese GM, Abraham DC, Mathai D, Thomas K, Aaron R, Kavita ML, Mathai E. Scrub typhus among hospitalized patients with febrile illness in South India: magnitude and clinical predictors. J Infect 2006 Jan;52(1):56-60.
Narvencar KP, Rodrigues S, Nevrekar RP, Dias L, Dias A, Vaz M, Gomes E. Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa. Indian J Med Res 2012 Dec;136(6):1020-1024.
Singh SP, Singh R, Ahmad N. A study of complications of scrub typhus in a tertiary health care institute of Uttarakhand, India. Int J Res Med Sci 2014 Feb;2(1):246-249.
Kundavaram APP, Das S, George VM. Scrub typhus presenting as an acute abdomen. J Glob Infect Dis 2014 Jan;6(1):17-18.
Anitharaj V, Stephen S, Pradeep J, Park S, Kim SH, Kim YJ, Kim EY, Kim YW. Serological diagnosis of acute scrub typhus in south India: evaluation of In Bios scrub typhus detect IgM rapid test, and comparison with other serological tests. J Clin Diag Res 2016 Nov;10(11):DC07-DC10.
Kumar R, Thakur S, Bhawani R, Kanga A, Ranjan A. Clinical profile and complications of scrub typhus: hospital-based study in sub-Himalayan region. J Assoc Physicians India 2016 Dec;64(12):30-34.
Paris DH, Shelite TR, Day NP, Walker DH. Unresolved problems related to scrub typhus: a seriously neglected life threatening disease. Am J Trop Med Hyg 2013 Aug;89(2): 301-307.
Yang CH, Young TG, Peng MY, Hsu GJ. Unusual presentation of acute abdomen in scrub typhus: a report of two cases. Zhonghua Yi Xue Za Zhi (Taipei) 1995 May;55(5):401-404.
Aung-Thu, Supanaranond W, Phumiratanaprapin W, Phonrat B, Chinprasatsak S, Ratanajaratroj N. Gastrointestinal manifestations of septic patients with scrub typhus in Maharat Nakhon Ratchasima Hospital. Southeast Asian J Trop Med Public Health 2004 Dec;35(4):845-851.
Hu ML, Liu WJ, Wu KL, Lu SN, Chiou SS, Kuo CH, Chuah SK, Wang JH, Hu TH, Chiu KW, et al. Abnormal liver function in scrub typhus. Am J Trop Med Hyg 2005 Oct;73(4):667-668.
Yi SY, Tae JH. Pancreatic abscess following scrub typhus associated with multiorgan failure. World J Gastroenterol 2007 Jul;13(25):3523-3525.
Lee CH, Lee JH, Yoon KJ, Hwang JH, Lee CS. Peritonitis in patients with scrub typhus. Am J Trop Med Hyg 2012 Jun;86(6):1046-1048.
