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VOLUME 8 , ISSUE 2 ( July-December, 2019 ) > List of Articles


Isoniazid.induced Thrombocytopenia in a Patient with Ocular Tuberculosis

Preeti Gupta, Hemant Kumar, Utkarsh Kumar Srivastava, Ajay Kumar Verma, Rishabh Chaudhary

Keywords : Antitubercular therapy, isoniazid, thrombocytopenia

Citation Information : Gupta P, Kumar H, Srivastava UK, Verma AK, Chaudhary R. Isoniazid.induced Thrombocytopenia in a Patient with Ocular Tuberculosis. Indian J Respir Care 2019; 8 (2):121-123.

DOI: 10.4103/ijrc.ijrc_48_18

License: CC BY-NC-SA 4.0

Published Online: 05-12-2022

Copyright Statement:  Copyright © 2019; Indian Journal of Respiratory Care.


Antitubercular therapy (ATT)-induced thrombocytopenia is a rare and serious adverse drug reaction which may be fatal if not identified timely. Although rifampicin is the common culprit ATT causing thrombocytopenia, other ATTs such as isoniazid have also been reported to cause thrombocytopenia. Here, we report a case of isoniazid-induced thrombocytopenia in a 56-year-old female with ocular tuberculosis who developed multiple purpura on both upper limbs, face, and oral cavity. Her condition improved with the withdrawal of isoniazid.

  1. Yakar F, Yildiz N, Yakar A, Kiliçaslan Z. Isoniazid- and rifampicin-induced thrombocytopenia. Multidiscip Respir Med 2013;8:13.
  2. Hansen JE. Hypersensitivity to isoniazid with neutropenia and thrombocytopenia. Am Rev Respir Dis 1961;83:744-7.
  3. Hashiguchi N, Furuyama K, Kim M, Hirose N. A case of pulmonary tuberculosis complicated with severe thrombocytopenia during treatment. Kekkaku 2012;87:345-9.
  4. Verma AK, Singh A, Chandra A, Kumar S, Gupta RK. Rifampicin-induced thrombocytopenia. Indian J Pharmacol 2010;42:240-2.
  5. George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, et al. Drug-induced thrombocytopenia: A systematic review of published case reports. Ann Intern Med 1998;129:886-90.
  6. Lee EJ, Lee SH, Kim YE, Lee SJ, Cho YJ, Jeong YY, et al. A case of isoniazid-induced thrombocytopenia: Recovery with immunoglobulin therapy. Intern Med 2012;51:745-8.
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