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VOLUME 8 , ISSUE 2 ( July-December, 2019 ) > List of Articles

Original Article

Clinicopathological Profile of Patients with Bronchogenic Carcinoma at a Tertiary Care Center in Western India

Dharitri Thakkar, Pradipkumar Damor, Kamlesh Vithalani

Keywords : Adenocarcinoma, lung cancer, smoking, squamous cell carcinoma

Citation Information : Thakkar D, Damor P, Vithalani K. Clinicopathological Profile of Patients with Bronchogenic Carcinoma at a Tertiary Care Center in Western India. Indian J Respir Care 2019; 8 (2):80-83.

DOI: 10.4103/ijrc.ijrc_47_18

License: CC BY-NC-SA 4.0

Published Online: 05-12-2022

Copyright Statement:  Copyright © 2019; Indian Journal of Respiratory Care.


Abstract

Background: Bronchogenic carcinoma is the most common malignancy all over the globe in terms of incidence and mortality, especially in males. Its increasing incidence in nonsmokers and females is also an important concern. Objectives: The objective of this study was to study various demographic, clinical, radiological, and histopathological features of patients with confirmed diagnosis of lung cancer. Patients and Methods: Patients with confirmed histopathological diagnosis of bronchogenic carcinoma attending a tertiary care center in western India were included in the study. Results: A total of 50 patients were studied. Of 50, 45 were male and 5 were female. Average age of the patient was 59.92 years. Forty-six (92%) patients were current or ex-smokers, whereas only 4 patients were never-smokers. Cough (90%) followed by chest pain (62%) was the presenting symptom. Soft-tissue density mass lesion was the most common radiographic finding. Adenocarcinoma (36%) followed closely by squamous cell carcinoma (32%) was the diagnosed histological subtype. Of 50, 9 (18%) patients had evidence of distant metastasis at the time of diagnosis. Conclusions: This study concludes that adenocarcinoma was the most common subtype even in smokers. A high index of suspicion and prompt investigations in a patient with respiratory symptoms should be employed to diagnose patients at an early stage.


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  1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan. iarc.fr. [Last accessed on 2018 Jun 25].
  2. Jindal SK, Behra D. Clinical spectrum of Primary lung cancer- review of Chandigarh experience of 10 years. Lung India 1990;37:343-7.
  3. Kaur H, Sehgal IS, Bal A, Gupta N, Behera D, Das A, et al. Evolving epidemiology of lung cancer in India: Reducing non-small cell lung cancer-not otherwise specified and quantifying tobacco smoke exposure are the key. Indian J Cancer 2017;54:285-90.
  4. Behra D. Epidemiology of lung cancer - Global and Indian perspective. J Indian Acad Clin Med 2012;13:131-7.
  5. Wynder EL, Hoffman D. Smoking and lung cancer. Scientific Challenges and Opportunities Cancer Res 1995;54:5284-95.
  6. Doll R, Hill AB. A study of the aetiology of carcinoma of lung. Br Med J 1952;2:1271.
  7. U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004.
  8. Doll R, Hill AB. Mortality in relation to smoking: Ten years' observations of British doctors. Br Med J 1964;1:1399, 1460.
  9. Janerich DT, Thompson WD, Varela LR, Greenwald P, Chorost S, Tucci C, et al. Lung cancer and exposure to tobacco smoke in the household. N Engl J Med 1990:323;632.
  10. Hammond EC, Selikoff IJ, Lawther PL, Seidman H. Inhalation of benzpyrene and cancer in man. Ann New York Academy of Sciences 1976;271:116-24.
  11. Brenner DR, McLaughlin JR, Hung RJ. Previous lung diseases and lung cancer risk: A systematic review and meta-analysis. PLoS ONE 2011;6:e17479. doi:10.1371/journal.pone.0017479.
  12. Pujari VV, Lokhande RM, Meshram SH. Clinical and pathological presentations of bronchogenic carcinoma in a tertiary care centre. J Evolution Med Dent Sci 2016;5:2968-71. DOI: 10.14260/jemds/2016/692.
  13. Dhandapani S, Srinivasan A, Rajagopalan R, Chellamuthu S, Rajkumar A, Palaniswamy P. Clinicopathological profile of lung cancer patients in a teaching hospital in South India. J Cardiothorac Med 2016;4:440-3.
  14. Sundaram V, Sanyal N. Clinicopathological profile of bronchogenic carcinoma in a tertiary care hospital in eastern part of India. Clin Cancer Investig J [serial online] 2014;3:220-4. Available from: http://www.ccijonline. org/text.asp?2014/3/3/220/132114. [Last cited 2018 Apr 28].
  15. Mohan A, Latifi AN, Guleria R. Increasing incidence of adenocarcinoma lung in India: Following the global trend? Indian J Cancer 2016;53:92-5.
  16. Gupta D, Boffetta P, Gaborieau V, Jindal SK. Risk factors of lung cancer in Chandigarh, India. Indian J Med Res 2001;113:142-50.
  17. Kashyap S, Mohapatra PR, Negi RS. Pattern of primary lung cancer among bidi smokers in North-Western Himalayan region of India. Lung Cancer 2003;41(Suppl 2):S111.
  18. Sharma CP, Behera D, Aggarwal AN, Gupta D, Jindal SK. Radiographic patterns in lung cancer. Indian J Chest Dis Allied Sci 2002;44:25-30.
  19. Saha A, Saha K, Ghosh S, Mitra M, Panchadhyayee P, Sarkar AP. Chest X-ray of lung cancer: Association with pathological subtypes. J Assoc Chest Physicians 2017;5:76-80.
  20. Malik PS, Sharma MC, Mohanti BK, Shukla NK, Deo S, Mohan A, et al. Clinico-pathological profile of lung cancer at AIIMS: A changing paradigm in India. Asian Pac J Cancer Prev 2013;14:489-94.
  21. Bhadke BB, Rathod RK, Deshmukh DG, Luniya AB, Mahajan P, Surjushe AU. Clinical profile of lung cancer in rural medical college of Maharashtra (India): A prospective study of three years. Int J Med Res Rev 2016;4:1063-71. doi:10.17511/ijmrr.2016.i06.34.
  22. Dey A, Biswas D, Saha SK, Kundu S, Kundu S, Sengupta A. Comparison study of clinicoradiological profile of primary lung cancer cases: An Eastern India experience. Indian J Cancer 2012;49:89-95.
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