Indian Journal of Respiratory Care

IJRC Email      Register      Login

VOLUME 10 , ISSUE S1 ( April, 2021 ) > List of Articles

Case Report and Literature Review

Emergency Management of Refractory Hypoxemia in Mechanically Ventilated Patients with COVID-19 Acute Respiratory Distress Syndrome

Subash P. Nandalan, Mathew Patteril

Keywords : COVID-19, refractory hypoxemia, ventilation

Citation Information :

DOI: 10.4103/ijrc.ijrc_7_21

License: CC BY-NC-SA 4.0

Published Online: 06-12-2022

Copyright Statement:  Copyright © 2021; Indian Journal of Respiratory Care.


Abstract

Covid-19 disease has had a significant impact on intensive care facilities worldwide. In ventilated patients with Covid-19 ARDS, refractory hypoxemia is a particularly challenging scenario. This article presents a case study and explores a systematic approach to the management of refractory hypoxemia. Current evidence base for Covid-19 medical management is discussed. It is emphasized that one must adhere to evidence based principles of ARDS management.


HTML PDF Share
  1. Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L, et al. COVID-19 pneumonia: Different respiratory treatments for different phenotypes? Intensive Care Med 2020;46:1099-102.
  2. ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: The berlin definition. JAMA 2012;307:2526-33.
  3. Acute Respiratory Distress Syndrome Network; Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-8.
  4. National Institute for Health and Care Excellence. COVID-19 Rapid Evidence Summary: Tocilizumab for COVID-19; 2021. Available from: https://www.nice.org.uk/advice/es33/chapter/Product-overview. [Last accessed on 2021 Mar 01].
  5. National Institute for Health and Care Excellence. COVID-19 Rapid Evidence Summary: Sarilumab for COVID-19; 2021. Available from: https://www.nice.org.uk/advice/es34/chapter/Product-overview. [Last accessed on 2021 Mar 01].
  6. National Institute for Health and Care Excellence. COVID-19 Rapid Guideline: Reducing the Risk of Venous Thromboembolism in Over 60s with COVID-19 (NG186); 2021. Available from: https://www.nice.org. uk/guidance/ng186. [Last accessed on 2021 Mar 01].
  7. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the treatment of COVID-19 - Final report. N Engl J Med 2020;383:1813-26.
  8. WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, et al. Repurposed antiviral drugs for Covid-19 - Interim WHO solidarity trial results. N Engl J Med 2021;384:497-511.
  9. Statement from the RECOVERY Trial Chief Investigators, on 15 January 2021. Available from: https://www.recoverytrial.net/news/statement-from-the-recovery-trial-chief-investigators-15-january-2021-recovery-trial-closes-recruitment-to-convalescentplasma-treatment-for-patients-hospitalised-with-covid-19. [Last accessed on 2021 Mar 01].
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.