Background: The incidence of spinal cord injury (SCI) varies but is estimated at 10–83 per million per year with most injured under the age of 25 years. Rehabilitation constitutes an important element of management of traumatic SCIs. However, due to lack of resources and awareness, this aspect is often neglected in developing countries. This results in poor functional outcome. Objectives: The study was conducted to assess functional improvement, in the form of self-care, transfer, and mobility pre and post a multipronged rehabilitation program in patients with SCI. The study also evaluated the impact of rehabilitation program in achieving different levels of independence, in SCI patients. Materials and methods: A prospective observational study carried out over the period of 1 year at a tertiary teaching hospital. Twenty patients with traumatic SCIs were included in the study and underwent a multipronged rehabilitation program. The program was specifically designed and tailored to ensure bedside mobility initially and then progressing to transfer and ambulatory training, and activity of daily livings (ADLs). Results: All patients showed improvements in functional outcome. The spinal cord independence measure (SCIM) showed a significant improvement in all areas of self-care, sphincter management, indoor and outdoor mobility. Ambulation status improved as a result of the program. Conclusion: A well-designed rehabilitation program has a significant impact on the functional outcome of patients with SCI. Rehabilitation should be promoted even if delayed in such patients.