Background: Lower extremity musculoskeletal disorders are common rheumatological conditions seeking medical advice. The diagnosis of these disorders is based primarily upon results of specific clinical tests. There are not many studies regarding the etiological profile of these conditions. The aim of this study was to assess the etiological profile of various musculoskeletal disorders of lower extremities among patients reporting to the Physical Medicine and Rehabilitation (PMR) Department of a tertiary care hospital in Kerala, India. Materials and methods: This study was carried out in the Department of Physical Medicine and Rehabilitation, Government T D Medical College, Alappuzha, during a period of one year from January 2017 to December 2017 to assess the etiological profile of various musculoskeletal disorders of upper extremities. This was a descriptive study conducted by evaluating the final diagnosis from the OP records of patients who were fully evaluated in the musculoskeletal pain clinic, which is functioning in the department. Results: There were 262 patients in the study. Age of patients ranged between 11 years and 79 years (mean age 46 years). 59.5% were females. 24.4% were manual labors. The most common etiology of lower limb musculoskeletal problems was osteoarthritis of knee (43.9%) followed by plantar fasciitis (12.6%) and post-traumatic stiffness of lower limb joints (11.8%). Other main causes were internal derangement of knee (6.1%), retrocalcaneal bursitis (4.2%), Achilles tendinitis and meralgia paresthetica (3.8% each), ankle sprain and osteoarthritis of hip (3.1% each). A few cases of osteoarthritis of ankle joints (1.9%), anserine bursitis (1.9%) and Osgood–Schlatter disease (1.1%) were also seen. More than half of the females in this study (51.2%) and one-third of males (33%) were suffering from osteoarthritis of knee. 19.2% of females in the study had plantar fasciitis, and only one male had plantar fasciitis. 68.6% of patients with osteoarthritis of knee were in the above 50 year age category. An important observation is that 31.3% with osteoarthritis of knee belonged to the less than 50-year age category. Plantar fasciitis was exclusively seen in less than 50-year age group. 96.8% with plantar fasciitis were in this category. A quarter of male patients presented with post-traumatic stiffness of lower limb joints (25.5%). Only 3.4% of females were having this problem. Conclusion: Osteoarthritis of knee, plantar fasciitis and post-traumatic stiffness of lower limb joints were the most common diagnoses reporting to PMR department of this tertiary care center with lower limb musculoskeletal problem. Osteoarthritis of knee was more common in females (p value 0.002). A statistically significant association also exist in plantar fasciitis among females (p value 0.000). Post-traumatic stiffness of lower limb joints was significantly more in males.