International Scientific Journals from Jaypee
Subscriber's Login
Home Instructions Editorial Board Current Issue Pubmed Archives Subscription Contact Us

List of All Articles

Symptoms of Oral Submucosal Fibrosis: Our Experience with Intralesional Injection Treatment
Mudit Mittal, Rajesh Yadav, PV Dhond, Shashi Kant
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:45-48]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1046 | FREE

Objective: This study evaluates the symptoms and effects of peroral intralesional injections in relieving the symptoms of oral submucosal fibrosis (OSMF) in our clinical settings.
Study design: Retrospective clinical review at a primary care hospital of 32 patients with extensive OSMF who underwent peroral intralesional injections of steroid, hyaluronidase, placentrex and lignocaine performed in office setting.
Results: The main symptoms were change in color of buccal mucosa, trismus, burning mouth, vesicles in oral cavity. All patients experienced considerable improvement in their symptoms over a duration of 2 to 6 weeks.
Conclusions: Though, a large number of Indian population is suffering and seeking treatment for OSMF, unfortunately not much has been done in this area. It is difficult to find studies on peroral intralesional injection technique. When there is lack of reliable evidence of oral submucosal fibrosis treatment, the old technique of peroral intralesion shots of steroid, hyaluronidase, placentrex in lignocaine is safe and effective in resolving the symptoms associated with OSMF. The therapy is very cost effective and also reduces the need of surgery.
Keywords: OSMF, Symptoms, Peroral injections.

Versatile Grafts and Flaps in Reconstruction of Oral and Maxillofacial Postsurgical Defects
Madhumati Singh, Anjan Shah, Shouvik Chowdhury
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:17-25]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1042 | FREE

Ablative surgery for head and neck tumors is associated with significant disfigurement and loss of function. The main aim of the surgeon is to provide functional ability and esthetics of the patient. Type and extent of tissue loss from surgery relates to loss of soft tissue and bone. Reconstructions of jaw and mouth defects represent a challenge to the surgeon and are most commonly indicated in patients with oral squamous cell carcinoma.4 Primary closure and the restoration of form, cosmetics and function are the goals of reconstructive surgery. Various techniques have been practiced, including grafts, local flaps, regional flaps and free vascularized flaps even with diverse options, each one has its inherent advantages and shortcomings.
This article highlights our experiences with various reconstructive options, best possible reconstructive method to be followed to minimize morbidity of the patient.
Keywords: Postsurgical defects, Tumors, Reconstruction.

An Overview of 22 Thyroglossal Cysts Managed in KVG Medical College
Sudhir M Naik, Sarika S Naik
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:5-9]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1040 | FREE

Background/objectives: Successful treatment of a thyroglossal duct cyst requires surgical extirpation of the cyst with its tract through the tongue base. Incomplete removal results in cyst recurrence, which is the most significant common complications of surgery. The Sistrunk’s procedure increases the chances of complete removal of all affected tissue.
Design: KVG Medical College, Department of ENT, Head and Neck Surgery.
Intervention: A total of 22 cases of thyroglossal cysts (primary and secondary) operated were included in our study.
Result: Recurrence was seen in two out of the 22 cases operated after one year of follow-up, and all the recurrences were seen in the secondary cysts.
Conclusions: Sistrunk’s operation is the treatment of choice for primary thyroglossal cysts. Secondary cysts should be treated with removal of core of tongue base muscle and foramen cecum mucosa along with hyoid and scarred cyst excision.
Keywords: Thyroglossal cyst, Sistrunk’s operation, Hyoid bone, Tongue base muscles.

SS Pagare, Sukhjinder Kaur Khosa
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:27-32]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1043 | FREE

Osteoradionecrosis (ORN) is a major complication of surgery or trauma in previously irradiated bone. This condition is often painful, debilitating and may result in significant bone loss. ORN of the mandible is the commonest site in patients who receive radiotherapy for head and neck cancer because of the relatively poor vascularization in this area. Risk factors include the total radiation dose, modality of treatment, fraction size and dose rate, oral hygiene, timing of tooth extractions as well as the continued use of tobacco and alcohol. Conversely, steroid use before or after radiation may have a protective effect related to the inhibition of the initial inflammatory phase of ORN. The management of this side effect is difficult and can result in bone or soft tissue loss, affecting the quality of life. The recommended treatment guidelines are irrigation, antibiotics, hyperbaric oxygen therapy and surgical techniques, including hemimandibulectomy and graft placements.
Keywords: Osteoradionecrosis, Radiotherapy, Hyperbaric oxygen therapy, Fibroatrophic mechanism.

Polymorphous Low-grade Adenocarcinoma of the Palate: Report of a Case and Review of Literature
Siddharth Gupta, C Anand Kumar, Namita Raghav
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:57-60]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1049 | FREE

Polymorphous low-grade adenocarcinoma (PLGA) is a malignancy arising predominantly from minor salivary glands. PLGAs account for 10% of all tumors and 25% of all malignancies of the minor salivary glands. It has been frequently described as occurring in hard or soft palate minor salivary glands; some cases being described in the tongue and in major salivary glands. We report a case of PLGA of the palate extending into the maxillary sinus and nasal cavity diagnosed on the basis of histopathology and treated by subtotal maxillectomy. The review of literature concerning clinical, histological and immunohistochemical features, as well as the proper management concerning this tumor is included.
Keywords: Minor salivary gland tumors, Malignant tumors, Adenocarcinoma, Maxillectomy.

Oral Radiation Mucositis: A Short Review
Rahul Krishnatry, Ankita A Nachankar, Tejpal Gupta, Jai Prakash Agarwal
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:37-43]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1045 | FREE

Oral radiation mucositis is one of the debilitating and dose-limiting acute toxicity during (chemo) radiation or for HNC having a major impact on the patient daily functioning, well-being and quality of life. The unplanned interruption of treatment secondary to mucositis may compromise the treatment and the outcomes if not adequately addressed. Recently, the integrated pathophysiological mechanism of radiation injury has been proposed, aiding development of certain targeted therapies for the prevention and treatment of oral mucositis. Although there are currently no approved agents or strategies that can reliably prevent or treat oral mucositis, there are several agents are under investigation and development. This is an exciting juncture in the development of drugs and drug delivery agents for radiation oral mucositis. This review is to have a peep into currently available options at present to optimally know when these agents can be used and what should be the direction of future research to maximize the therapeutic benefit.
Keywords: Mucositis, Oral mucositis, Radiotherapy.

Retroauricular Hairline Approach for Excision of Second Branchial Cleft Cysts
Brad LeBert, Sean R Weiss, Jonas T Johnson, Rohan R Walvekar
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:49-52]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1047 | FREE

Objective: To report our preliminary experience with a retroauricular hairline incision (RAHI) for excision of second branchial cleft cysts (SBCC) and to present a relevant literature review.
Study design: Retrospective case series.
Methods: A retrospective chart review was conducted of two consecutive patients diagnosed with SBCC who underwent surgical removal via a RAHI. Relevant demographic, clinicopathological and radiological data were recorded. A web-based search was conducted to identify relevant scientific literature on "retroauricular hairline incision/approach" in order to present a systematic review of current literature.
Results: In both cases, the SBCC (6.0 and 3.8 cm) could be safely excised without major complications. One patient developed a temporary hypoesthesia of earlobe. None of the patients had a postoperative infection, hematoma, spillage of cyst fluid or necrosis of the skin flap. All patients were satisfied with the cosmetic outcome of the procedure (100%). The incisions healed well without any evidence of hair loss or keloid formation.
Conclusion: In conclusion, the RAHI offers an excellent surgical outcome and superior cosmetic result with no proven increased risks to the patients who require surgical excision of a benign SBCC.
Keywords: Retroauricular, Upper neck mass, Branchial cleft cyst, Lateral cervical cyst, Postauricular.

Primary Small Cell Carcinoma of Nasal Cavity Presenting as Unilateral Blindness
Ashutosh Chauhan, NC Chakarborty, Pramod Nath, Manomoy Ganguly
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:61-63]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1050 | FREE

Primary sinonasal small cell carcinomas are extremely rare lesions. We present a case of 29-year-old male patient, who initially presented with recurrent right sided nasal obstruction and occasional epistaxis, but came to medical attention when he developed progressive deterioration of vision in ipsilateral eye. Radiological examination showed a tumor with epicenter in right nasal cavity with extensive local infiltration. The histopathology picture and immunohistochemistry profile of the tumor showed it to be a primary small cell neuroendocrine tumor. Extensive imaging studies revealed no other site of primary. He was treated with induction chemotherapy followed by concomitant chemoradiotherapy. Complete clinical response was seen and the patient has been disease free since last 20 months. The report discusses the diagnostic criteria which differentiates this extremely rare but aggressive tumor from a much more common and more indolent tumor, esthesioneuroblastoma.
Keywords: Nasal cavity, Paranasal sinuses, Neuroendocrine carcinoma, Small cell carcinoma.

Spontaneous Small Bowel Perforations in Patients Receiving Radiotherapy or Chemotherapy for Advanced Head and Neck Cancer
Muttagi Sidramesh, Pankaj Chaturvedi
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:67-68]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1052 | FREE

Gastroduodenal perforations are known to occur due to various causes. However, such problems involving small bowel and manifesting spontaneously, especially in a head and neck cancer patient, undergoing chemoradiation has never been described in the literature. We report three cases of head and neck cancer that were undergoing treatment (one case curative and two cases palliative), during which small bowel perforation manifested requiring urgent surgical intervention. We seek to highlight this problem, so as to ascertain the possible mechanisms of its causation, identify a group of patients at risk, evolve possible preventive strategies and facilitate earlier diagnosis and treatment.
Keywords: Spontaneous, Ileal perforation, Oral cancer, Chemoradiation.

Metastatic Implantation of Head and Neck Squamous Cell Cancer at PEG Tube Site Exit— An Unusual Relapse Site: A Case Report and Review of Literature
Vijay Palwe, Kaustav Talpatra, Umesh Mahantshetty, Seethalaxmi Viswanathan
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:53-56]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1048 | FREE

Background: The placement of percutaneous endoscopic gastrostomy (PEG) tubes is a common procedure in patients with head and neck cancer who require adequate nutrition because of the inability to swallow before or after surgery and adjuvant therapies. A potential complication of percutaneous endoscopic gastrostomy tubes is the metastatic spread from the original head and neck tumor to the gastrostomy site.
Methods: This is a case of a 55-year-old male with a (cT4N3M0) stage IV squamous cell carcinoma of the oropharynx who underwent percutaneous endoscopic gastrostomy tube placement prior to commencement of definitive chemoradiation therapy and 7 months thereafter developed metastatic spread to the gastrostomy site. Tumor was treated with radiation therapy. A review of the published literature regarding the subject is done. The pull-through method of gastrostomy tube placement had been used in our patient as well as in the majority of the other cases reviewed in the literature.
Conclusions: There is a small but definite risk for tumor implantation in the gastrostomy site when using the pull technique in patients with active head and neck cancer. The direct implantation of tumor through instrumentation is the most likely explanation for metastasis; however, hematogenous seeding is also a possibility. Careful assessment of the oropharynx and hypopharynx before PEG tube placement and the use of alternative techniques for enteral access in patients with untreated or residual malignancy are recommended to minimize this risk.
Keywords: PEG site metastasis, Tumor implantation, Head and neck cancer.

Branchial Cyst: An Unusual Presentation as Intrathoracic Extension and Hoarseness of Voice
Sunil Kumar, HP Singh, Ambrish Kumar, Nuzhat Husain, SP Agarwal
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:69-71]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1053 | FREE

Branchial cleft cysts usually present as a unilateral, fluctuant soft tissue swelling that is localized deep to the anterior border of sternocleidomastoid in the lateral aspect of the neck. They are often noticed late in childhood or early adulthood. It is important that clinical diagnosis and, in some cases, appropriate imaging is performed, so that definitive treatment may be carried out. The authors present an unusual case of a 35-year-old man who presented with hoarseness of voice associated with a lateral neck mass that extended retrosternally.
Keywords: Branchial cyst, Intrathoracic extension, Hoarseness of voice.

Clinicopathological Study of Ameloblastomas: Case Study in Tribal Areas
Naik Balachandra Ramachandra
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:1-4]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1039 | FREE

During the period of 10 years, we have received 19 ameloblastoma specimens for opinion. The purpose of this report is that many studies on ameloblastoma were published from western countries, but not a single study from this region, which is an area of tribal people. Hence, this study is taken up to analyze for various parameters, and to compared with the western countries studies and also to inform the new and rare findings which is not yet published that is, the malignant ameloblastoma metastasis in soft tissue with intercellular bridges. Specimens were processed for macroscopic and microscopic analysis by routine methods. Majority of analysis were similar to the western countries studies. Malignant ameloblastoma metastasis in soft tissue gave us surprise. Ameloblastoma in tribal people did not have differences with western countries, but we got a new thing which enriches the behavior of malignant ameloblastoma.
Keywords: Malignant ameloblastoma in soft tissue.

Epidermal Growth Factor Receptor and the Squamous Cell Cercinoma of the Head and Neck
Sudhir V Nair
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:33-36]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1044 | FREE

Epidermal growth factor receptor (EGFR) is over expressed in 80 to 90% of squamous cell carcinomas of the head and neck (HNSCC) and plays a role in its pathogenesis and clinical course. Several EGFR-targeted therapies have therefore been developed and tried in clinical trials in the past decade resulting in the approval of cetuximab, an EGFR monoclonal antibody as a treatment agent for HNSCC by US FDA. Even though, EGFR monotherapy so far does not have a significant effect, cetuximab in combination with radiotherapy has enhanced the overall effect of radiotherapy in these patients without enhancing significantly the overall toxicity. Hence, understanding the mechanisms of resistance and exploring new combination treatments with EGFR targeting agents are important.
Keywords: EGFR, Cetuximab, Gefitinib, Erlotinib, Targeted therapy, HNSCC, Chemoradiotherapy.

Pediatric Infraorbital Nerve Schwannoma: A Rare Clinical Entity
Raviraj GA, Thomas Rony, Dhanraj GA, Vishal US Rao
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:73-75]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1054 | FREE

This report elaborates a rare case of infraorbital nerve Schwannoma in an 8-year-old boy who presented with the recurrent progressively increasing swelling over the right cheek following initial treatment. The mass was excised surgically via a facial approach. Infraorbital nerve sheath tumors occurring in the pediatric age are rare and can be often mistaken for infectious causes in this age group. Surgery remains the mainstay of treatment in these tumors. Early diagnosis and prompt surgical treatment can serve to minimize the treatment related morbidity arising from multiple interventions while avoiding undue apprehension. Pediatric infraorbital schwannomas, although a rare entity, should be considered in the differential diagnosis of long standing pediatric facial swellings.
Keywords: Schwannoma, Infraorbital nerve, Surgery.

Vocal Cord Paralysis Following Percutaneous Embolization of a Vagal Paraganglioma
Vishal Rao, Raghavendra KS, Purushottam Chavan, Ashok Shenoy M
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:65-66]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1051 | FREE

Tumors of the head and neck region that frequently require embolization include meningiomas, paragangliomas and angiofibromas, owing to their rich vascularity. Serious complications following embolization are uncommon. We report an unusual case of vocal cord palsy following embolization.
Keywords: Vocal cord paralysis, Paraganglioma, Vagus nerve.

Choice of the Optimal Volume of Surgery for Patients with Sporadic Medullary Thyroid Cancer
Anatoly F Romanchishen, OV Lisovsky, KV Vabalayte
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:11-15]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1041 | FREE

Objectives: Influence of lymphatic metastases at immediate and follow-up results of patients’ surgical treatment is controversial, especially for sporadic medullary thyroid carcinoma (SMTC).
Methods: A total of 3330 thyroid cancer patients were operated on (1973-2009), among them 226 (6.8%) were medullary thyroid cancer (MTC) patients. In 11 observations, MTC appeared as a part of MEN syndrome. Sporadic character of disease was confirmed in 215 (95.1%) cases. There were 140 (80.8%) females and 33 (19.2%) males (4.2:1.0) with average age 48.6 ± 2.7. Long-term results (1-40 yrs) were investigated in 173 (94.2%) cases. All SMTC patients were divided in to three groups. Group 1 made of 80 (46.2%) T1- 3N0M0, Group 2 of 47 (27.3%) T1-3N1a-bM0, Group 3 of 46 (26.6%) T4N1a-bM0 patients.
Results: Group1: Organ-sparing operations were carried out in 59 (73.7%), thyroidectomies in 21 (26.3%) patients. Multicentric tumor growth (MTG) was observed in 19.1%: in T1 cases - 5.7%, T2 - 20.5%, T3 - 46.7%. All patients underwent ipsilateral prophylactic central neck dissection (CND). Average period of postoperative observation (APPO), 12.0 ± 1.7. 5 years survival rate made 98.4%, 10-91.7%. Local relapse of MTC was found in one patient (in contralateral thyroid lobe). Group 2: Organ-sparing operations were carried out in 20 (42.6%), thyroidectomies’27 (57.4%) with curative central or central and lateral lymphadenectomy (LAE). MTG took place in 47.2%. Six group metastases only (T1a) were found in 38.9% and CND was performed. In other cases (61.1%), CND, lateral and mediastinal (8.3%) LAE were performed. APPO correspondent to 10.8 + 2.1 years. Repeated LAE because lymphatic metastases were carry out in 15 (31.9%) patients through 7.2 ± 2.4 years in average after initial operations. Tumor relapses were not found in thyroid remnant. Five-year survival rate made 89.2%, 10-67.8%. Group 3: MTG was observed in 64.3%. Central compartment group lymphatic metastases were revealed in 93.3%, in 2 to 5 groups - 86.7%, in mediastinum - 38.5%, distant metastases - in 22.0%. Combined operations were performed in 58.9%, palliative in 45 (26.6 %) cases. Operations were completed by tracheostomy in 38.4%. Adjuvant therapy (X-ray, chemotherapy) was applied in 28.9%. Postoperative lethality made 6.5%. APPO corresponded to 3.3 ± 0.8 (1-10 yrs). During first year, eight patients have died. Five-year survival rate made 32.4%.
Conclusion: Detection of regional metastases of SMTC during the first patient presentation significantly worsen survival rate. Early diagnosis of SMTC by calcitonin level detection is the best way to improve results of treatment. Organ-sparing thyroidectomies with mandatory ipsilateral prophylactics CND are justified only at T1N0M0 sporadic MTC.
Keywords: Medullary thyroid carcinoma, Surgery treatment of medullary thyroid cancer.

17.  Editorial
Jatin P Shah
[Year:2011] [Month:January-April] [Volume:2 ] [Number:1] [Pages:75] [Pages No:v]
Full Text PDF | FREE


© Jaypee Brothers Medical Publishers (P) Ltd.