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1.  ORIGINAL ARTICLES
Comparative Study of the Efficacy of Curcumin and Turmeric Oil as Chemopreventive Agents in Oral Submucous Fibrosis: A Clinical and Histopathological Evaluation
Deepa Das A, Anita Balan, Sreelatha KT
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:88-92]
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Abstract
Background and Objectives: Oral submucous fibrosis (OSMF), A chronic disease characterized by fibrosis of oral mucosa is a premalignant condition carrying a high-risk of malignant transformation. So far none of the treatment modalities have proved curative. Turmeric and its active ingredient “curcumin’’are being studied upon as chemopreventive agents in various diseases. This study was carried-out to evaluate the efficacy of turmeric dispensed in two forms, namely curcumin capsules and turmeric oil in patients with OSMF both clinically and histopathologically and to compare them with conventional chemopreventive treatment.
Materials and Methods: Forty eight patients who were clinically and histopathologically confirmed as having OSMF were selected for the study and were randomly divided into three groups. Group I patients were given curcumin capsules, Group II turmeric oil and Group III; the control group were provided with multinal tablets. The patients were called upon every 15 days for 3 months of treatment and then followed up, every month for 6 months. The results were analyzed with Anova Technique and Students’’ test.
Results: After treatment and follow-up statistically significant improvement was observed in the clinical signs and symptoms of patients treated with curcumin and turmeric oil when compared to those with multinal. Positive changes were also observed in the histopathological examination after treatment with curcumin and turmeric oil.
Conclusion: The therapy with curcumin and turmeric oil is beneficial, affordable and noninvasive form of treatment in patients with OSMF.
Keywords: Curcumin, turmeric oil, oral submucous fibrosis.

 
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2.  ORIGINAL ARTICLES
Midpalatal Suture Ossification and Skeletal Maturation: A Comparative Computerized Tomographic Scan and Roentgenographic Study
Manish Thadani, Usha Shenoy, Bhaskar Patle, Anshu Kalra, Shirish Goel, N Toshinawal
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:81-87]
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Abstract
The main aim of this study was to evaluate and compare the ossification of the midpalatal suture using cross-sectional maxillary occlusal radiograph and computerized tomographic scan of the hard palate in the axial direction. The percentage of the ossification thus obtained was correlated with the skeletal maturation indicators like (CVMI categories and MP3 stages) in Group I subjects (8.0-16.0 years) and with chronological age in group II subjects (16.1-25.0 years). The radiograph of the middle phalanx of the third finger and lateral cephalogram in occlusion were taken for the Group I subjects. The total sample size of the study comprised of 21 subjects with transverse maxillary deficiency. The percentage of the ossification of the midpalatal suture was calculated using suture obliteration index described by Persson and Thilander. The results of the study revealed that the total amount of ossification of the MPS in Group I subjects with computerized tomographic scan (22.56 ± 3.62%) was significantly less compared to cross-sectional maxillary occlusal radiograph (58.22 ± 3.79) at the end of skeletal maturation (p < 0.001). There was sudden spurt in the ossification of the MPS after CVMI category 4/MP3 H stage. In Group II subjects CT scan again showed significantly less amount of the ossification (40.78 ± 19.73) compared to maxillary occlusal radiograph (60.32 ± 14.41) in the total length of the MPS (p < 0.05). Thus CT scan of the hard palate showed less than 50% of the midpalatal suture ossification at the age of 25 years approximately. This was due to advantages of the computed tomographic technology, i.e. no superimposition of the overlying and adjacent structure, exact localization and accurate assessment of the MPS ossification over the conventional radiography.
Keywords: Midpalatal suture ossification, computerized tomographic scan, occlusal radiograph, skeletal maturation.

 
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3.  CASE REPORTS
Neurofibroma of Lip: Report of a Rare Case
N Kannan, Rajendra Patil, Sreenivasulu Pattipati
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:113-115]
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Abstract
Neurofibroma is a benign tumor of neural tissue origin. It most frequently involves the skin and rarely the oral mucosa. The nature of the disease has been recognized as hereditary with an autosomal dominant trait with variable penetrance. It has been reported to occur 1 in every 3000 births.
The oral lesions occur as discrete, nonulcerated nodules, which tend to be of the same color as the normal mucosa. Usually occurs on the buccal mucosa, palate, alveolar mucosa, vestibule and the tongue.
An interesting case of asymptomatic swelling of the lower lip since 20 years is presented. The swelling was gradual in onset and slowly increased in size in the first year of its appearance, there after there was no increase in size of the swelling and it remained stable until the patient reported at our clinic. It was a solitary diffuse, lobulated swelling of lower lip extending distally from left commissure, mesially crossing the midline, anteriorly from vermillion border of lower lip, posteriorly extending into labial vestibule. Excisional biopsy was performed and histological examination revealed interlacing fascicles of elongated cells with very dark staining nuclei and focal areas resembling Antoni A pattern, which confirmed the lesion to be neurofibroma of lip.
Keywords: Solitary labial neurofibroma, nonmyelinating Schwann cells, NF1genes, perineural cells, mast cells, endothelial cells, mitogens, neurofibromin.

 
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4.  RESEARCH ARTICLES
Estimation and Comparative Evaluation of Serum Iron, Copper, Zinc and Copper/Zinc Ratio in Oral Leukoplakia, Submucous Fibrosis and Squamous Cell Carcinoma
Apeksha R Balpande, RS Sathawane
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:73-76]
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Abstract
Higher incidence of oral cancer and precancer in Indian population necessitates in depth probing of various etiological and contributory factors for its early diagnosis and prognosis. In the present study serum iron, copper, zinc levels and Cu/Zn ratio were estimated in control and study groups [oral leukoplakia (OL), oral submucous fibrosis (OSMF), oral squamous cell carcinoma (OSCC)]. Estimation of these trace elements was done by colorimetric method using semi automated analyzer. Serum iron level and Cu/Zn ratio were significantly reduced while serum copper was increased significantly in OL, OSMF, and OSCC. The comparison of these trace elements between study groups was also found to be significant. Thus, assessment of Cu, Zn, Fe and Cu/Zn ratio can be used as auxiliary test to clinicopathological diagnosis and prognosis of oral precancer and cancer.
Keywords: OSMF, OL, OSCC, trace elements, iron, copper, zinc.

 
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5.  RESEARCH ARTICLES
Study on the Prevalence of Hypertension in Dental Out-patient Population
Shobha Basavaraj Sikkerimath, Ramesh DNSV
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:77-80]
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Abstract
Higher incidence of oral cancer and precancer in Indian population necessitates in depth probing of various etiological and contributory factors for its early diagnosis and prognosis. In the present study serum iron, copper, zinc levels and Cu/Zn ratio were estimated in control and study groups [oral leukoplakia (OL), oral submucous fibrosis (OSMF), oral squamous cell carcinoma (OSCC)]. Estimation of these trace elements was done by colorimetric method using semi automated analyzer. Serum iron level and Cu/Zn ratio were significantly reduced while serum copper was increased significantly in OL, OSMF, and OSCC. The comparison of these trace elements between study groups was also found to be significant. Thus, assessment of Cu, Zn, Fe and Cu/Zn ratio can be used as auxiliary test to clinicopathological diagnosis and prognosis of oral precancer and cancer.
Keywords: OSMF, OL, OSCC, trace elements, iron, copper, zinc.

 
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6.  Guest Editorial
Guest Editorial
D Koteeswaran
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:V-VII]
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7.  CASE REPORTS
An Incidental Finding of Enlarged Genial Tubercles in a Case of Oral Carcinoma
SC Selvamuthukumar, Nalini Aswath, B Karthika
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:99-101]
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Abstract
The genial tubercles are a group of bony extensions that surround the lingual foramen bilaterally in the midway between the superior and inferior borders of the lingual surface of the mandible. Enlargement of genial tubercle occurs very rarely due to hypertrophy. This article focuses on a rare case showing hypertrophy of the genial tubercles.
Keywords: Genial tubercles, mental spine, hypertrophy, computed tomography.

 
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8.  CASE REPORTS
Nonsyndromic Familial Hyperdontia: Two Case Reports and Review of Literature
Pradhuman Verma, Jatindra Sachdeo, Kanika Verma
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:105-108]
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Abstract
Nonsyndromic familial hyperdontia/supernumerary teeth is a rare disorder of odontogenesis characterized by an excess number of teeth with familial background. They can be supplemental (resembling natural teeth), conical, tuberculate or molariform.
Early clinical and radiographic examination of the supernumerary teeth allow for optimal yet minimal treatment. This article reports two rare cases of nonsyndromic hereditary hyperdontia both in the maxillary anterior region. First case report with bilateral mesiodentes palatal to the central incisors in sister and brother and second case report with presence of fused mesiodentes in father and conical mesiodens in son. Though the exact etiology of this dental anomaly remains unclear, genetics as key factor in development of supernumerary teeth is highlighted.
Keywords: Supernumerary teeth, tuberculate tooth, mesiodens.

 
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9.  CASE REPORTS
Bilateral Dentigerous Cyst: An Unusual Case Report and Review of Literature
Shweta Tikekar, Shirish S Degwekar, Rahul R Bhowate
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:116-118]
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Abstract
Dentigerous cysts are the most common developmental cysts of the jaws, most frequently associated with impacted mandibular third molar teeth. Bilateral dentigerous cysts are rare and occur typically in association with a developmental syndrome. The reported occurrence of bilateral dentigerous cysts in the absence of a syndrome is rare and, to date, only 17 cases have been described. The following is a report of a case of unusual bilateral nonsyndromic dentigerous cysts associated with developing mandibular second premolars and a review of literature.
Keywords: Dentigerous cyst, mandibular second premolar, deciduous mandibular second molar.

 
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10.  CASE REPORTS
Ameloblastic Fibroodontoma Case Report: Diagnostic Valuable Aid of CT Scan in Identification of Mineralized Component
Devi Charan Shetty, Aadithya B Urs, Puneet Ahuja, Kaveri Hallikeri, Mayura Paul
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:102-104]
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Abstract
Many lesions that occur in the jaw have a similar radiographical appearance and it is often difficult to differentiate among them. Despite development of various cross-sectional imaging modalities, the radiograph still remains the first and the most important investigation. Radiographical evaluation of jaw lesion characteristics, which include location, margin, density, relation to tooth, along with knowledge of the clinical data, generally helps in narrowing the diagnosis. With advancing technology today the multi-row scanners are used for an increasing number of indications for routine examinations. Most major research facilities use 64-slice scanners on a routine clinical basis. Computed tomography (CT) scans are not ideal for imaging soft tissues such as muscles, joints or brain, but are perfect for detecting air or calcium. CT provides very good spatial resolution, that is the ability to distinguish between two separate structures that are very close together. But precision in identifying these calcified structures could be upregulated by the use of this normal routine specialized technique along with a software, which uses in its principle methods to quantify and qualitate the density.
Keywords: Computed tomography, calcified masses, ameloblastic fibro-odontoma.

 
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11.  REVIEW ARTICLE
Ectodermal Dysplasia: Report and Analysis of Eleven South Indian Patients with Review of Literature
Renuka Ammanagi, Vaishali Keluskar, Anjana Bagewadi
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:93-98]
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Abstract
Ectodermal dysplasia represents a rare syndrome affecting two or more ectodermally derived structures. The condition is thought to occur in approximately 1 in every 100,000 live births. It affects men more frequently and severely, while women being the carriers and heterozygote usually show minor defects. There are more than 150 different variants of ectodermal dysplasia (ED) reported in the literature. Most commonly encountered among them is hypohidrotic ED which frequently exhibits the most severe dental anomalies like hypodontia or anodontia along with hypohidrosis and hypotrichosis. Here we make an attempt to collectively report and discuss eleven South Indian patients who reported to our department during the year 1998 to 2004. An added emphasis is laid on family history of consanguineous marriage among the parents of these patients.
Keywords: Hypohidrotic ectodermal dysplasia, hypodontia, hypohidrosis, hypotrichosis, anhidrotic, consanguineous marriage.

 
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12.  CASE REPORTS
Xeroderma Pigmentosum: Variable Expressions among Three Siblings
M Srinivasa Raju, GN Suma, Ravi Prakash SM, Sumit Goel
[Year:2010] [Month:April-June] [Volume:22 ] [Number:2] [Pages:118] [Pages No:109-112]
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Abstract
Xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner. It is characterized by photosensitivity, pigmentary changes, premature skin aging, and malignant tumor development. The frequency of this disorder is approximately 1 case per 250,000 population. Two important causes of mortality are metastatic malignant melanoma and squamous cell carcinoma. Here xeroderma pigmentosum in three siblings presenting with variable expressions is reported. The severity of the condition was more in one of the more sun exposed sibling and had more signs of malignant lesions. Intraoral pigmentation was also present in all the three siblings.
Keywords: XP, photosensitivity, pigmentary changes, premature skin aging, malignant tumors, defective nucleotide excision repair, siblings.

 
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