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1.  PUBLIC HEALTH
Areca Nut or Betel Nut Control is Mandatory if India Wants to Reduce the Burden of Cancer Especially Cancer of the Oral Cavity
Chaturvedi Pankaj
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:17-20]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1003 | FREE

Abstract
A lesser known reason of epidemic proportion of oral cancer in India is the rampant use of Areca nut chewing. Just like tobacco, areca nut or betel nut is a psychostimulant, an addictive substance and a carcinogen. The cancer causing properties of areca nut have been well-reported in animal, human and epidemiologic studies. The World Health Organization and International Agency for Research on cancer classified areca nut as a Group 1 human carcinogens with sufficient evidence of increased risk of submucus fibrosis (precancerous oral lesion) and cancers of the oral cavity, pharynx, and esophagus. This was based upon several studies from India, Bangladesh, Pakistan and Taiwan. Cancers caused by betel nut chewing also shows a strong dose–response relationship for frequency and duration of chewing. It is postulated that areca nut-specific N-nitroso compounds converted from alkaloids are responsible for oral and pharyngeal cancer. There are several other reports that have linked areca nut chewing (with or without tobacco) with hepatocellular carcinoma, cholangiocarcinoma, cancers of the larynx, stomach, lung and cervix in humans.
Keywords: Areca nut, betel nut, oral cancer, supari cancer.

 
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2.  REVIEW ARTICLE
Feeding Tube Enterostomies in Upper Aerodigestive Tract Cancers
Saha Saumitra, Bose Anandabrata, Chowdhary Pankaj
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:9-16]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1002 | FREE

Abstract
Establishment and maintenance of safe access is crucial for long-term enteral nutrition in patients with head-neck and esophagogastric cancers. Tube enterostomies such as gastrostomy and jejunostomy are being increasingly used with wider use of chemoradiation and adjuvant therapy following surgery. This article reviews the currently available enteral access techniques by the open and percutaneous route and their indications, safety, effectiveness and role in modern oncological practice.
Keywords: Feeding gastrostomy, jejunostomy, percutaneous techniques.

 
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3.  CASE REPORTS
Carcinoma Larynx in Children
Julaha Manish, Chaturvedi Pankaj, Pai Prathamesh, Chaukar Devendra Pantvaidya Gauri, D Cruz Anil
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:49-51]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1010 | FREE

Abstract
Carcinoma of the larynx is uncommon in children 15 years of age or younger. Because of low index of suspicion, the diagnosis of childhood laryngeal carcinoma is often delayed. Other factors contributing to its delayed diagnosis are the similarity of its early symptoms to those of other benign, common childhood conditions and the relative difficulty encountered during pediatric laryngeal examination. Treatment of pediatric laryngeal cancers is challenging, because no guidelines are available.
   We believe that every single case of childhood laryngeal cancer should be reported, because of paucity of literature on this childhood entity, it is limited only to case reports and reviews. This makes treatment options and outcomes difficult to interpret.
Keywords: Larynx, squamous cell carcinoma, pediatric.

 
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4.  ORIGINAL ARTICLE
Postoperative Radiotherapy in Hypopharyngeal Cancer: Single-institution Outcome Analysis
Gupta Tejpal, Chopra Supriya, Agarwal Jai Prakash, Ghosh-Laskar Sarbani D’Cruz Anil, Chaturvedi Pankaj, Dinshaw Ketayun
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:1-8]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1001 | FREE

Abstract
Purpose: To retrospectively review the outcomes of adjuvant postoperative radiotherapy (PORT) following surgery in patients with advanced hypopharyngeal cancer treated at an academic tertiary referral center.
Methods: Data of patients treated with curative intent in a single radiotherapy unit over a 15-year period (1990-2004) with upfront surgery followed by PORT was retrieved from an electronic database. Local control (LC), locoregional control (LRC) and disease-free survival (DFS) were considered as outcome measures.
Results: The study dataset constituted 159 patients with a median age of 55 years (range 30-79 years). Patients underwent either radical surgery (total laryngectomy with or without pharyngectomy) or voice-conserving surgery. All patients underwent appropriate comprehensive neck dissection. The median radiotherapy dose was 60 Gy (inter-quartile range 50-60 Gy). With a mean follow-up of 21 months (inter-quartile range 6-29 months), the 3-year LC, LRC, and DFS was 87.8%, 70.3% and 62.2% respectively. Cut margin negativity and pyriform sinus subsite predicted for improved LRC and DFS on univariate analysis. Cut margin status was the only independent predictor of outcome on multivariate analysis.
Conclusion: Hypopharyngeal cancer characterized by advanced disease at presentation. Definitive surgery (either voice-conserving or radical) followed by adjuvant radiotherapy provides good LRC and DFS and continues to remain a valid upfront treatment option for advanced hypopharyngeal cancer. Cut margin status and primary subsite are important determinants of outcome.
Keywords: Hypopharyngeal cancer; postoperative radiotherapy; and prognosis.

 
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5.  CORRESPONDENCE
Platysma Sign – A Clinical Manifestation of Infiltration of Platysma and the Subcutaneous Tissue by Large Neck Node
Chaturvedi Pankaj, Agarwal Jai Prakash
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:53-54]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1011 | FREE

Abstract
We propose a simple clinical sign that is seen in certain patients with bulky nodal metastases. The fundamental basis of this sign is the direct infiltration of platysma by the nodal mass causing contracture of the muscle fibers of platysma called “Platysma sign”. The exact definition of this sign is “ puckering of the platysma and the overlying skin like an inverted Japanese fan”. This puckering always happens below the level of nodes and finishes at the level of the clavicle. This clinical sign can serve as an instant reminder to the clinician and avoid oversight of the skin/platysma infiltration. Assessment of the integrity of the neck skin overlying a large neck nodes must be undertaken while examining a head and neck cancer patient with bulky neck metastasis. Infiltration of platysma or the skin is an important finding in the staging and treatment of the neck disease.
Keywords: Platysma, neck node, extracapsular spread, clinical sign, metastasis.

 
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6.  CASE REPORTS
An Unusual Case of Epidermal Inclusion Cyst of Maxilla
Vaidya Abhishek, Sharma Arpit, Dabholkar Jyoti, Raut Abhijit
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:43-47]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1009 | FREE

Abstract
Introduction: Epidermal inclusion cyst is a relatively common condition usually associated with trauma, with characteristic presentation, and seen in the extremities. However, it is an uncommon entity in the head and neck region.
Objective: The purpose of this paper is to report the unusual presentation of epidermal inclusion cyst in the maxilla without any definitive history of trauma and to review the concerned English language literature.
Conclusion: In the absence of any definitive history of trauma, only a thorough clinical examination along with characteristic radiological imaging and histopathological findings will help in diagnosing epidermal inclusion cyst.
Keywords: Epidermal inclusion cyst; epidermoid cyst; maxillary cyst.

 
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7.  CASE REPORTS
Intracapsular Carcinoma ex Pleomorphic Adenoma in the Buccal Space: Management Dilemma
Dandekar Mitali, Chaukar Devendra, Kane Shubhada, Juvekar Shashikant D’Cruz Anil
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:21-24]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1004 | FREE

Abstract
Objective: Rare case of intracapsular carcinoma ex pleomorphic adenoma in the buccal space with focus on its appropriate management.
Method: Case report with review of current literature on buccal space lesions and intracapsular carcinoma ex pleomorphic adenoma.
Result: Although salivary gland tumors are common, intracapsular carcinoma ex pleomorphic adenoma is a rare entity especially within the buccal space with no similar case report in the current literature.
Conclusion: Our case is unusual due to its unusual presentation in the buccal space and pathological features. This case report also highlights issues regarding its appropriate management.
Keywords: Pleomorphic adenoma, salivary gland neoplasm, facial neoplasm.

 
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8.  CASE REPORTS
Colossal Malignant Nonteratoid Medulloepithelioma of the Eye with Unusual Metastases: The Natural History
Qureshi Sajid
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:39-42]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1008 | FREE

Abstract
Background: Medulloepithelioma is rare intraocular tumor seen predominantly in children, and arising mainly from undifferentiated nonpigmented epithelium of the ciliary body.
Methods: We present a typical neglected case of malignant nonteratoid medulloepithelioma of the eye with extensive metastases to the facial soft tissue parotid and cervical lymph nodes.
Results: An aggressive surgical approach with orbital exenteration and comprehensive disease clearance with total parotidectomy and neck dissection augmented by postoperative radiotherapy was utilized after initial unsuccessful chemotherapy.
Conclusions: The present case highlights the natural history of untreated medulloepithelioma of the eye. Colossal growth at the primary site with extensive regional lymph node metastases develops without distant metastases. Complete surgical excision supplemented with postoperative radiotherapy should be considered even in the setting of advanced locoregional disease.
Keywords: Medulloepithelioma, nonteratoid, metastasis, natural history.

 
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9.  CASE REPORTS
Nonsyndromic Type of Multiple Basal Cell Carcinoma
Chaturvedi Pankaj, Ghatge Amit, D Cruz Anil, Pai Prathamesh, Chaukar Devendra Pantvaidya Gouri
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:25-28]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1005 | FREE

Abstract
We report a case of nonsyndromic type of multiple basal cell carcinoma associated purely with actinic keratoses. A 69-year-old Indian male had suffered from multiple, variable-sized papules and nodules on the face, neck and chest for 13 years previous to treatment. He had no history of arsenic intake, irradiation, herb medication, or exposure to chemical warfare gases. Family histories for basal cell carcinoma and xeroderma pigmentosum were negative. Classical features of Gorlin's syndrome were conspicuous by their absence. Histopathologically, the tumors revealed typical findings of basal cell carcinoma arising from actinic keratoses. The case in point is a very rare and unique case in itself as being nonsyndromic, nonhereditary and occurring in the absence of various other environmental conditions as already mentioned in literature.
Keywords: Multiple basal cell carcinoma, actinic keratosis.

 
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10.  CASE REPORTS
Solitary Fibrous Tumor Presenting as a Parapharyngeal Mass
Ruta Goregaonkar, Seethalakshmi Viswanathan, Pai Prathamesh, Chaturvedi Pankaj, Kane SV
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:29-33]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1006 | FREE

Abstract
Solitary fibrous tumors (SFT) rarely occur in the neck region and can be easily mistaken for more common tumors if the index of suspicion is not high. They are characterized by remarkable histologic variability. However, immunopositivity for CD34 and Bcl2 with immunonegativity for other markers aid in establishing the diagnosis. Distinction from the other common benign entities is essential, as SFT are tumors of low grade aggressiveness and unpredictable biologic behavior. Complete resection is the key feature determining outcome.
Keywords: Parapharyngeal, solitary, fibrous, tumor.

 
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11.  Editorial
Editor-in-Chief
Chris de Souza
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:v]
Full Text PDF | FREE

 
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12.  Editorial
Associate Editor
Pankaj Chaturvedi
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:vii]
Full Text PDF | FREE

 
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13.  CASE REPORTS
Osteoradionecrosis Complicating Mandibulotomy
Kolur Trupti, Rao Vishal, Purushottam Chavan, Umesh Kavita, Shenoy Ashok
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:35-37]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10001-1007 | FREE

Abstract
Osteoradionecrosis (ORN) of the mandible is a well acknowledged entity following radiotherapy for oral cancers. Mandibular surgery prior to radiotherapy adds an additional risk factor for osteoradionecrosis. Management of these cases poses various hurdles including added morbidity, additional cost for treatment of ORN and suboptimal dose delivery to the tumor bed. This case reports elaborates the issues related to mandibular surgery in patients requiring adjuvant radiotherapy, precautions to be taken and the management of ORN in a postsurgical setting.
Keywords: Osteoradionecrosis, radiotherapy.

 
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14.  JOURNAL SCAN FOR IJHNS
JOURNAL SCAN FOR IJHNS
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:55-59]
Full Text HTML | Full Text PDF | FREE

 
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15.  ANNOUNCEMENT
ANNOUNCEMENT
[Year:2010] [Month:January-April] [Volume:1 ] [Number:1] [Pages:61] [Pages No:61]
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