JAYPEE JOURNALS Subscriber's Login
  International Scientific Journals from Jaypee
 
Home Instructions Editorial Board Current Issue Pubmed Archives Subscription Advertisement
 
 
List of All Articles
 
 
  Viewed
1.  MINI REVIEWS
Hepatitis B Virus-related Liver Disease Burden in South Asia
Abhijit Chowdhury
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:44-46]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1011 | FREE

Hepatitis B is major health concern globally, specially in the Asia-Pacific region. The virus results in countless premature mortalities and greater number of morbidities. While the scientific community is more focused toward HBV-related liver disease burden, the toll of this virus on our economies remain largely undermine. Proper planning and active participation of the government machinery and decision makers are vital to the best utilization of resources of our resource-constrained countries for the implementing best possible measures against hepatitis B.
Keywords: Hepatitis B, Disease severity, Economic impact.
How to Cite: Chowdhury A. Hepatitis B Virus-related Liver Disease Burden in South Asia. EuAsian J Hep Gastro. 2011;1(2):44-46
 
974
2.  REVIEW ARTICLES
Genetic Diversity of HBV Genotypes/Subgenotypes and Their Correlation with Disease Progression
Rajesh Kumar, Jasbir Singh
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:53-67]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1014 | FREE

Hepatitis B virus (HBV) infection remains a global health problem and a public health threat in the present era. It is estimated that 2 billion people are infected with HBV and 350 million people suffer from chronic HBV infection in the world. India is a prosperous country in Asia and has peculiar geographical presence which is responsible for evasion of this land by traders and invaders in past and resulted in gene influx due to invasion and/or anthropological migrations in the past. Moreover, recent increase in trade, trafficking and use of illicit drugs has also considerably influenced the epidemiology of HBV in different parts of India. However, data on the genotypes/subgenotypes diversity of HBV in India is scanty. In this manuscript, the information available on the genetic diversity of HBV genotypes and subgenotypes in India and in world and their relationship with the disease progression has been reviewed.
Abbreviations: HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LC: Liver cirrhosis; RFLP: Restriction fragment length polymorphism; ORF: Open reading frame; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; PCR: Polymerase chain reaction, ELISA: Enzyme-linked immunosorbent assay; ALT: Alanine aminotransferase; IFN: Interferon; PEG-IFN: Pegylated IFN.
Keywords: Hepatitis B virus, Genotype, Subgenotype, Serotype, Interferon-a, Lamivudine, Adefovir dipivoxil.
How to Cite: Kumar R, Singh J. Genetic Diversity of HBV Genotypes/Subgenotypes and Their Correlation with Disease Progression. EuAsian J Hep Gastro. 2011;1(2):53-67
 
935
3.  ORIGINAL ARTICLES
Gemstone Spectral Monochromatic CT Imaging: Detection and Classification of Focal Liver Lesions in Patients with Pancreatic Cancer
Hu Shengping, Wang Mingliang, Wu Zhiyuan , Zhao Xuesong, Miao Fei
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:77-82]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1017 | FREE

Objective: To analyze the diagnostic performance of gemstone spectral monochromatic CT imaging in the detection and classification of focal liver lesions in patients with pancreatic cancer.
Methods: We retrospectively studied 32 pancreatic cancer patients with 55 focal liver lesion images (19 cysts and 36 metastases) conducted by gemstone spectral CT. We obtained the focal liver lesions and the pancreatic iodine concentration from the iodine-based material decomposition images. This was further normalized to that of aorta. Receiver-operator characteristic curves to determine the diagnostic sensitivities and specificities of correctly diffentiating liver metastases from cysts were calculated. Imaging results were correlated with findings of intraoperative surgical (n = 13), imaging follow-up, ultrasound findings and percutaneous ethanol therapy (n = 19).
Results: Gemstone spectral CT played a significant role in differentiating focal liver metastases from liver cysts. The parameters we drew could provide extra quantitative data.
Conclusion: The gemstone spectral monochromatic CT scanner provides not only the processed polychromatic images, including arterial and portal phase images, but also extra quantitative data.
Abbreviations: CT: Computed tomography; GSI: Gemstone spectral imaging; MD: Material decomposition; HDCT: Helical dynamic CT, AP: Arterial phase; PP: Portal phase; ROC: Receiver operating characteristics; MDCT: Multidetector CT
Keywords: Gemstone spectral CT, GSI CT, Focal liver lesions, Pancreatic cancer.
How to Cite: Shengping H, Mingliang W, Zhiyuan W, Xuesong Z, Fei M. Gemstone Spectral Monochromatic CT Imaging: Detection and Classification of Focal Liver Lesions in Patients with Pancreatic Cancer. EuAsian J Hep Gastro. 2011;1(2):77-82
 
902
4.  MINI REVIEWS
Hepatitis B: From Blumberg to Bangladesh
Salimur Rahman
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:42-43]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1010 | FREE

Bangladesh has made significant progress in all aspects, if hepatitis B management in the recent years. On one hand, we have local generics of most approved antivirals against hepatitis B, including pegylated interferon, which has brought down treatment cost significantly. On the other extreme, significant progress has also been made in the research arena and good quality papers on hepatitis B from Bangladesh are now being published regularly in impact factor journals. Several clinical trials have already been completed, while others are ongoing, which is testimony to the very promising side of hepatology in Bangladesh as a whole.
Keywords: Hepatitis B, Bangladesh.
How to Cite: Rahman S. Hepatitis B: From Blumberg to Bangladesh. EuAsian J Hep Gastro. 2011;1(2):42-43
 
784
5.  ORIGINAL ARTICLES
Prevalence of Transfusion Transmitted Infection in Healthy Blood Donors in Sir Salimullah Medical College, Dhaka, Bangladesh
Shasanka Kumar Saha, Ranjit Kumar Banik, Mili Rani Saha, Munshi M Habibullah, Mamun-Al-Mahtab
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:68-70]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1015 | FREE

Background: Transfusion of blood and blood components, as a specialized modality of patient management, saves millions of lives worldwide each year and reduce morbidity. It is well-known that blood transfusion is associated with a large number of complications.
Objective: The objective of the present study was to assess the status of transfusion transmitted infections (TTI) among the apparently healthy donors so as to increase the awareness of complications of blood transfusion and make the clinicians more vigilant with regard to judicious use of blood.
Methods: A total of 21,966 units of donor’s blood were screened from January 2007 to December 2010 at blood bank of Sir Salimullah Medical College, Mitford Hospital, Dhaka. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria. All healthy blood donors were 18 to 60 years old.
Result: Prevalence of hepatitis B virus (HBV), HCV, HIV and syphilis were 2.19, 0.25, 0.06 and 0.15% respectively. No blood donor tested showed positivity for malarial parasite. With the implementation of strict donor selection criteria and use of sensitive screening test, it may be possible to reduce the incidence of TTI in the Bangladeshi population.
Abbreviations: HBsAg: Hepatitis B surface antigen; HCV: Hepatitis C virus; HIV 1 and 2: Human immunodeficiency virus 1 and 2; VDRL: Venereal disease research laboratory test; HBV: Hepatitis B virus; NAT: Nucleic acid amplification testing; TTI: Transfusion transmitted infection.
Keywords: Transfusion transmitted infection (TTI), Seroprevalence, Human immunodeficiency virus (HIV), Hepatitis C virus.
How to Cite: Saha SK, Banik RK, Saha MR, Habibullah MM, Al-Mahtab M. Prevalence of Transfusion Transmitted Infection in Healthy Blood Donors in Sir Salimullah Medical College, Dhaka, Bangladesh. EuAsian J Hep Gastro. 2011;1(2):68-70
 
773
6.  MINI REVIEWS
Combating Hepatitis B: The Tripura Model
Pradip Bhaumik, Ajit Ranjan Choudhury, Priyabrata Sinha
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:39-41]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1009 | FREE

Although hepatitis B is a major public health problem globally, mass vaccination against this virus is yet to be implemented in many countries of the world, including in India, which happens to be one of the most populous nations in the globe. Hepatitis Foundation of Tripura has become a role model in combating this virus in the small north-eastern Indian state of Tripura. With infrastructural help from the Tripura Government, the foundation has done a commendable job of vaccinating 0.25 million out of 3.65 million population of the state, setting an unique example of public partnership in sustaining hepatitis B virus.
Keywords: Hepatitis B, Prevention, Tripura.
How to Cite: Bhaumik P, Choudhury AR, Sinha P. Combating Hepatitis B: The Tripura Model. EuAsian J Hep Gastro. 2011;1(2):39-41
 
567
7.  ORIGINAL ARTICLES
Histopathological Assessment of Liver Biopsy Specimen in the Context of HBV DNA and HBeAg in Patients with Chronic Hepatitis B
Naznin Nahar, Mamun-Al-Mahtab, AJE Nahar Rahman, Sheikh Mohammad Fazle Akbar, Saequa Habib
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:83-88]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1018 | FREE

Background: There is lack of consensus if hepatitis B virus (HBV) DNA can be regarded as a surrogate marker of liver damages in patients with chronic hepatitis B (CHB).
Methods: A total of 77 patients with CHB were enrolled in this study. The sera of the patients were tested for HBV DNA and hepatitis B e antigen (HBeAg). The extent of hepatitis and hepatic fibrosis was assessed by liver biopsy.
Results: Out of total of 77 patients with CHB, 29 were HBeAg-positive and 48 were HBeAg-negative. Twenty-seven of 29 HBeAg-positive patients and eight of 48 HBeAg-negative patients had high levels of HBV DNA (HBV DNA>105 copies/ml). The extent of hepatitis was minimal or mild in most HBeAg-positive CHB patients (27 of 29) irrespective of the levels of HBV DNA in the sera. Moderate levels of hepatitis were seen in two HBeAg-positive patients and five HBeAg-negative patients. Moderate levels of hepatic fibrosis were seen in four of eight HBeAg-negative patients with high HBV DNA.
Conclusion: This study shows that HBV DNA and HBeAg do not reflect the extent of hepatitis or hepatic fibrosis in CHB patients of Bangladesh. Combination of different HBV-related markers with liver biopsy is required for proper diagnosis and management of CHB in Bangladesh.
Abbreviations: HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; ALT: Alanine aminotransferase; CHB: Chronic hepatitis B; HAI: Histology activity index.
Keywords: HBV DNA, HBeAg, Hepatitis, Hepatic fibrosis, Bangladesh.
How to Cite: Nahar N, Al-Mahtab M, Rahman AN, Akbar SMF, Habib S. Histopathological Assessment of Liver Biopsy Specimen in the Context of HBV DNA and HBeAg in Patients with Chronic Hepatitis B. EuAsian J Hep Gastro. 2011;1(2):83-88
 
461
8.  ORIGINAL ARTICLES
Differentially Altered Plasma Proteins in Patients diagnosed with Alcoholic and Nonalcoholic Fatty Liver Disease
Kamlesh K Bhopale, Dhananjaya Nauduri, Kizhake V Soman, Gagan K Sood, Anthony Okorodudu, GAS Ansari, Bhupendra S Kaphalia
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:89-99]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1019 | FREE

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are major health problems. Although both diseases follow a similar course of disease progression from an early reversible fatty liver stage to severe necroinflammation with or without fibrosis and cirrhosis, the mechanisms of ALD and NAFLD are not well understood. This preliminary study was conducted to determine blood alcohol concentration (BAC) and altered proteins and fatty acid ethyl esters (FAEEs, nonoxidative metabolites of ethanol) in the plasma of patients diagnosed with ALD or NAFLD. Differentially altered proteins were identified by two-dimensional gel electrophoresis and mass spectrometry, FAEEs by gas chromatography and BAC by an enzymatic method. Precursors of complement C3, complement C6 and serum amyloid A-4 protein, and Ig gamma-3 chain C region were significantly decreased in ALD vs controls (group 1). Haptoglobin precursor was the only altered protein (increased) in NAFLD vs controls (group 2). However, significantly increased levels of precursors of complements C3, C4-B and C6 and decreased levels of immunoglobulin J chain and Leucine-rich alpha-2 glycoprotein precursor were observed in NAFLD vs ALD (group 3). These results indicate potential of precursors of complements C3 and C6 and haptoglobin for the differential diagnosis of ALD and NAFLD. Although high BAC and plasma FAEEs levels in the ALD group appear to be associated with chronic alcohol abuse, biological significance of endogenous biosynthesis of FAEEs yet to be established. Therefore, a detailed proteomic and lipidomic study need to be conducted in larger cohorts to understand the etiopathogenesis of ALD and NAFLD.
Keywords: Alcoholic liver disease, Nonalcoholic fatty liver disease, Fatty acid ethyl esters, Complements.
How to Cite: Bhopale KK, Nauduri D, Soman KV, Sood GK, Okorodudu A, Ansari G, Kaphalia BS. Differentially Altered Plasma Proteins in Patients diagnosed with Alcoholic and Nonalcoholic Fatty Liver Disease. EuAsian J Hep Gastro. 2011;1(2):89-99
 
441
9.  CASE REPORTS
Spontaneous Rupture of Spleen in Immunoglobulin Light Chain Amyloidosis: A Case Report and Review of Literature
Sunil Taneja, Piyush Ranjan, Sanjay Khanna, Nandini Vasdev, SK Sama, Anil Arora
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:100-102]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1020 | FREE

Rupture of spleen in absence of trauma is very rare and can occur in certain pathologic conditions. Amyloidosis involves spleen and splenomegaly has been reported in 4 to 13% of patients; however, splenic rupture has rarely been reported in amyloidosis. Here, we report a case of spontaneous splenic rupture in a patient with immunoglobulin light chain amyloidosis.
Abbreviations: AL: Immunoglobulin light chain; CT: Computed tomography.
Keywords: AL amyloidosis, Spleen rupture, Kappa light chain, Plasma cells.
How to Cite: Taneja S, Ranjan P, Khanna S, Vasdev N, Sama SK, Arora A. Spontaneous Rupture of Spleen in Immunoglobulin Light Chain Amyloidosis: A Case Report and Review of Literature. EuAsian J Hep Gastro. 2011;1(2):100-102
 
438
10.  MINI REVIEWS
Immunotherapy for Chronic Hepatitis B: Will this Lead to Rome?
Sheikh Mohammad Fazle Akbar, Mamun-Al-Mahtab
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:47-48]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1012 | FREE

The entity and concept of immune therapy against chronic infections and cancers is still elusive. Credible preclinical studies and clinical trials are scare in this field due to improper understating about cellular and molecular mechanism of these diseases. In addition, immune interventional strategies against these diseases have not been properly formulated. A sketch about immune pathogenesis of these diseases and interventional strategies has been formulated in this communication.
Keywords: Immune therapy, Chronic infection, Cancers, Strategy.
How to Cite: Akbar SMF, Al-Mahtab M. Immunotherapy for Chronic Hepatitis B: Will this Lead to Rome. EuAsian J Hep Gastro. 2011;1(2):47-48
 
424
11.  ORIGINAL ARTICLES
Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B
Tarek A Besheer, Mahmoud M El-Bendary, Khaled R Zalata, Hossam E Zaghalol
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:71-76]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1016 | FREE

Background: To evaluate the usefulness of biochemical markers for prediction of fibrosis in chronic hepatitis B. Materials and methods: This study was carried out on 133 patients with chronic hepatitis B. The diagnostic accuracy of four noninvasive liver fibrosis markers; matrix metalloproteinase-2 (MMP-2), hyaluronic acid (HA), aspartate aminotransferase (AST) to platelet ratio index (APRI) and FIB-4 was evaluated.
Results: The levels of HA and MMP-2 were increased along with the severity of fibrosis. The cutoff value for HA was 265 ng/ml for predicting liver cirrhosis, whereas cutoff value for MMP-2 was 860 ng/ml. The cutoff value for APRI for detecting severe fibrosis (F3 and F4) was = 0.9. Finally, cutoff value for FIB-4 was = 0.9 for assessment of severe fibrosis in chronic hepatitis B.
Conclusion: HA, MMP-2, APRI and FIB-4 could be clinically useful as noninvasive markers for detection of severe fibrosis in chronic hepatitis B.
Abbreviations: HBV: Hepatitis B virus; HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; CHB: Chronic hepatitis B; HDV: Hepatitis delta virus; HBsAg: Hepatitis B surface antigen; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; APRI: AST to platelet ratio index; PLT: Platelet; ULN: Upper limit of normal; HA: Hyaluronic acid; MMP-2: Matrix metalloproteinase-2; ROC: Receiver operating curve.
Keywords: APRI, CHB, FIB-4, HA, Hepatic fibrosis, MMP-2.
How to Cite: Besheer TA, El-Bendary MM, Zalata KR, Zaghalol HE. Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B. EuAsian J Hep Gastro. 2011;1(2):71-76
 
411
12.  MINI REVIEWS
Update on Management of Viral Hepatitis B
Desmond Wai
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:49-52]
Full Text HTML | Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10018-1013 | FREE

Management of hepatitis B has gone a long way since the introduction of lamivudine and interferon. Today, we have several much more potent oral antivirals for hepatitis B, which are associated with much less resistance. Pegylated interferon has the path for immune modulation and newer immune modulators are in the pipeline. Options of combination therapy are being evaluated, while treatment is being individualized. Although the best treatment for hepatitis B is yet to be identified, the prospects are brighter than ever before.
Keywords: Hepatitis B, Management.
How to Cite: Wai D. Update on Management of Viral Hepatitis B. EuAsian J Hep Gastro. 2011;1(2):49-52
 
396
13.  Editorial
Editorial
Prof Hasan Ozkan
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:v]
Full Text PDF | Abstract | FREE

It is With great pleasure that I start my speech by saying that another dream of mine has come true. In 1996, we established the Euroasian Gastroenterological Association in Ankara, Turkey. Our Aim was to form a new scientific zone between the East Europ
 
351
14.  Guest Editorial
World Hepatitis Day 2012
Mamun-Al-Mahtab
[Year:2011] [Month:July-December] [Volume:1 ] [Number:2] [Pages:63] [Pages No:vi]
Full Text PDF | Abstract | FREE

Liver diseases due to hepatitis viruses dominantcauses of morbidity and mortality Bangladesh, a country with 150 million people, which developing but not so advanced health care delivery system
 
288
        
 
     
 

© Jaypee Brothers Medical Publishers (P) Ltd.