Article Details

2015 | April-June | Issue2
Hepatitis B Diagnosis in Blood Bank: Evaluation and Challenges
Amruta Sonawane Patil, Aruna Shankarkumar
Author Affiliation
Amruta Sonawane Patil : MGM Institute of Health Sciences, Kamothe, Navi Mumbai, Maharashtra, India

Aruna Shankarkumar : Indian Council of Medical Research (ICMR), KEM Hospital, Parel, Mumbai Maharashtra, India



Hepatitis B virus (HBV) presents a higher residual risk of transmission by transfusion than hepatitis C virus (HCV) or human immunodeficiency virus (HIV). While most infectious blood units are removed by screening for hepatitis B surface antigen (HBsAg), there is clear evidence that transmission by HBsAg-negative components occurs, in part, during the serolo g ically negative window period, but more so during the late stages of infection.
To encourage voluntary blood donation should be the first step of prevention. To reduce the risk of transfusion-associated hepatitis B, test for anti-HBc immunoglobulin M may be included in routine screening of donors’ blood, as it has been proved to be an excellent indicator of occult HBV during window period. However, awareness and education of donors regarding the modes of HBV transmission, a stringent one-to-one donor screening and increasing the voluntary donor base should also be implemented to minimize the rate of transfusion-associated hepatitis B.

Keywords: Hepatitis B, HBV, Diagnosis, HBsAg, Nucleic acid testing, Voluntary blood donation.

How to cite this article: Patil AS, Shankarkumar A. Hepatitis B Diagnosis in Blood Bank: Evaluation and Challenges. MGM J Med Sci 2015;2(2):83-89.

Source of support: Nil

Conflict of interest: None

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