Article Details

2014 | October-December | Issue4
What will Change with Highly Sensitive Troponin Assays?
Jaskanwal DS Sara, Allan S Jaffe
Author Affiliation
Jaskanwal DS Sara : Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN, USA

Allan S Jaffe : Cardiovascular Division, Mayo Clinic, Rochester, MN, USA



In the not too distant future, high-sensitivity cardiac troponin assays will be introduced for use in the United States. They bring with them many exciting new opportunities within cardiovascular practice including the ability to confirm or refute a diagnosis of acute myocardial infarction more rapidly as well as the ability to risk stratify and guide treatment decisions in patients with a variety of acute and chronic noncoronary diseases. However, clinicians and researchers must be aware of the new facets introduced with troponin testing and, in particular, the new issues that will arise with high sensitivity assays. Emphasis must also be placed on reiterating the same principles of the effective use of troponin testing that applied to conventional assays, as these are likely to become even more important. This review outlines a number of important issues related to high sensitivity assays with a focus on their use in acute hospital settings.

Keywords: Troponin, Highly sensitive troponin assay, Acute coronary syndrome, Non-ST segment elevation myocardial infarction, Acute myocardial infarction.

Abbreviations: ACS: Acute coronary syndrome; AMI: Acute myocardial infarction; COPD: Chronic obstructive pulmonary disease; cTn: Cardiac troponin; CV: Coefficient of variation; ED: Emergency department; hs-cTn: High-sensitivity cardiac troponin; JVD: Jugular venous distension; LVH: Left ventricular hypertrophy; MRI: Magnetic resonance imaging; ng/ml: Nanogram per milliliter; PE: Pulmonary embolism; URL: Upper reference limit.

How to cite this article: Sara JD, Jaffe AS. What will Change with Highly Sensitive Troponin Assays? MGM J Med Sci 2014; 1(4):174-186.

Source of support: Nil

Conflict of interest: None

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