Article Details

2014 | January-March | Issue1
Review Article
Diagnosis and Effective Management of Preterm Labor
Robert E Garfield, Miha Lucovnik, Ruben J Kuon
Author Affiliation
Robert E Garfield : St Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA

Miha Lucovnik : Division of Perinatology, University Medical Center, Ljubljana, Slovenia

Ruben J Kuon : University Hospital, Heidelberg, Heidelberg, Germany



Despite extensive research, we are still unable to diagnose, prevent and treat preterm labor. Monitoring efficacy of interventions that would allow this is largely biased by the inability to accurately identify true labor with the currently used crude technology. Progestin supplementation appears to be a promising approach to both preventing initiation of preterm labor and treating it once it is already established, given progesterone’s role in maintaining pregnancy as well as support from basic and clinical research. However, the questions on mechanisms of action, optimal progestin formulation, dose, route and timing of administration remain unanswered. We have established and reported noninvasive means to accurately monitor cervical ripening, by measuring collagen light-induced fluorescence (LIF) and myometrial contractility, by measuring uterine electromyography (EMG). By accurately assessing the two components of parturition, cervical LIF and uterine EMG can help to identify effective prevention strategies and treatment of preterm labor.

Keywords: Labor and delivery, Uterine electromyography, Cervical light-induced fluorescence, Progesterone, 17 alphahydroxyprogesterone acetate.

How to cite this article: Garfield RE, Lucovnik M, Kuon RJ. Diagnosis and Effective Management of Preterm Labor. MGM J Med Sci 2014;1(1):22-37.

Source of support: Nil

Conflict of interest: None

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