Changes in the level of various biochemical parameters play a significant role in the physiopathology of sickle cell disease (SCD). The aim of this study is to determine the level of urinary micoalbumin and plasma level of ascorbic acid and uric acid in subjects suffering from sickle cell anemia. A total of 30 subjects consisting of both males and females whose age range varied from 10 to 30 years were included in the study. The urinary albumin/creatinine ratio invariably increased in all studied subjects as compared with the control subjects. The level of ascorbic acid in the plasma significantly declined in SCD subjects when compared with that of control subjects (p < 0.05). Also, the decrease in level of uric acid in plasma of SCD patients was significant as compared with the control subjects. Significant changes in these biochemical parameters thus could be used as reliable markers in nephropathy in sickle cell patients and thus in the management of the disease.
Keywords: Ascorbic acid, Microalbuminuria, Nephropathy, Sickle cell disease.
How to cite this article: Patra PK, Khodiar PK, Sahu D, Sahu GK. Alterations in Urinary Microalbumin and Serum Antioxidants in Sickle Cell Disease. Indian J Med Biochem 2016;20(1):1-5.
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Conflict of interest: None