Aim: The aim of present study was to assess the role of E-cadherin in oral carcinogenesis by comparing their expressions in normal oral mucosa, oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC).

Materials and methods: To elucidate the pattern of E-cadherin expression in oral carcinogenesis, 21 archival cases of formalinfixed paraffin-embedded sections of OSCC, 21 OED, and 7 normal oral mucosa samples as control were used for the study.

Results: We observed reduction/loss of E-cadherin in membranous expression pattern and staining intensity with progression from dysplasia to oral cancer.

Conclusion: A decrease in staining intensity and loss of E-cadherin membranous expression were noted from dysplasia to carcinoma, suggesting its role as a tumor suppressor gene.

Clinical significance: E-cadherin can be used as a biomarker to assess and evaluate the progression and prognosis of oral dysplastic lesions and OSCC.

Keywords: Cell adhesion molecules, Dysplastic epithelium, E-cadherin, Immunohistochemistry, Tumor markers.

How to cite this article: Gupta A, Sharma S, Batra M, Abidullah M, Bhuvinder S, Katragadda P. Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study. J Contemp Dent Pract 2018;19(9):1105-1110.

Source of support: Nil

Conflict of interest: None