Introduction: Thyroid hormones influence renal development, renal hemodynamics, glomerular filtration rate (GFR), electrolytes, and water homeostasis. The location of the present study is situated at Darjeeling district of West Bengal, which is a part of sub-Himalayan Terai regions with high prevalence of thyroid dysfunctions, especially hypothyroidism. The objective of this observational cross-sectional study is to substantiate the effects of thyroid hormonal status on kidney by estimating serum creatinine, serum urea, albumin-to-creatinine ratio (ACR), and estimated GFR (eGFR) among drug naïve primary hypothyroid patients, hypothyroid patients under treatment for more than 2 months, and age- and sex-matched control group.

Materials and methods: The study includes 48 patients with primary hypothyroidism in a drug naïve status, 40 hypothyroid patients under treatment, and 44 healthy control in the age group of 25 to 55 years. The collected blood and urine samples from the study population have been estimated for the study parameters. Both Chronic Kidney Disease Epidemiology (CKDEPI) equation and four-variable Modification of Diet in Renal Disease (MDRD) Study equation were used to calculate eGFR.

Results: The mean values of serum creatinine, urea, and ACR are significantly increased among untreated patients with primary hypothyroidism, with the decrease in the eGFR, in comparison to healthy control group (p < 0.001); whereas patients on treatment for hypothyroidism show fall in serum creatinine, serum urea, and ACR level, with increase in eGFR values compared with drug naïve primary hypothyroid patients (p < 0.001). In addition, the results of eGFR and ACR are significantly correlated with thyroid-stimulating hormone (TSH) values.

Conclusion: Statistically significant alteration in renal function parameters is associated with untreated primary hypothyroidism. Moreover, with the initiation of the treatment for the same can cause reversal of the altered status of renal function.

Keywords: Albumin-to-creatinine ratio, Estimated glomerular filtration rate, Hypothyroidism, Microalbumin, Renal function.

How to cite this article: Saha S, Nath I, Das MS, Mukherjee S. A Study on Renal Function Status of Patients with Hypothyroidism attending a Tertiary Care Hospital in North Bengal. Indian J Med Biochem 2018;22(1):10-17.

Source of support: Nil

Conflict of interest: None