Introduction: AYUSH 82 powder is an Ayurvedic antidiabetic formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of AYUSH, Government of India. The antidiabetic potential of AYUSH 82 powder along with its two new dosage forms—AYUSH 82 mixture extract and AYUSH 82 compound extract—has been established to be mediated via α-amylase inhibitory property, insulin-dependent glucose uptake in skeletal muscle cell line (C2C12 myotubes).

Aim: In the current study, we investigated the in vivo antidiabetic potential of new dosage forms of AYUSH 82—AYUSH 82 mixture extract and AYUSH 82 mixture extract + Shilajit.

Results and conclusion: Oral administration of AYUSH 82 mixture extract for 28 days twice daily could significantly increase serum insulin levels, reduction in Glucose Area under Curve 0 to 90 minutes, fed blood glucose, and triglyceride levels. It also showed improvement in histopathological grading, which resulted in protecting the pancreatic islets from progressive damage. Addition of Shilajit to AYUSH 82 mixture extract did not contribute much improvement in biochemical parameters related to diabetes.

Keywords: AYUSH 82 mixture extract, Shilajit streptozotocin, Type II diabetes mellitus.

How to cite this article: Setia M, Gupta A, Rai RK, Nigam A, Srikanth N, Dhiman KS. Evaluation of Antidiabetic Potential of New Dosage Forms of AYUSH 82 in Streptozotocin-induced Type II Diabetic Rats. J Drug Res Ayurvedic Sci 2017; 2(4):274-280

Source of support: Nil

Conflict of interest: None