Introduction: Intravenous dexmedetomidine (Dex) has been used in various doses with bupivacaine spinal anesthesia (SA) for various surgeries. A study was conducted to observe the effects of two doses of intravenous Dex on sensory, motor, and hemodynamic parameters and sedation during SA.

Materials and methods: In this prospective, randomized double-blind study, two groups of 35 patients, each undergoing hysterectomy, received SA with 15 mg hyperbaric bupivacaine. After subarachnoid block, group I received 1 μg/kg bolus and group II received 0.5 μg/kg bolus of Dex. The maintenance infusion of 0.5 μg/kg/hr was given to all patients. Duration of sensory block (SB) and motor block (MB), cephalad spread, quality of analgesia, and sedation score (SS) were studied with hemodynamic parameters. The data were analyzed using Student’s t-test, and p < 0.05 was considered statistically significant.

Results: Demographic data, duration, and type of surgery were comparable. The duration of SB was significantly more in group I (133.03 ± 8.29 min) compared with group II (113.83 ± 11.18 min). The duration of MB was significantly more in group I (224.03 ± 10.32 min) than group II (200.43 ± 9.73 min). The height and quality of blocks were comparable. The SS was significantly more in group I (3.40 ± 0.55) compared with group II (3.143 ± 0.35). The incidence of bradycardia was more in group I than in group II, but that of hypotension was comparable.

Conclusion: A 1 μg/kg bolus and 0.5 μg/kg/hr maintenance dose regime of Dex with bupivacaine SA is more suitable for hysterectomy as compared with 0.5 μg/kg bolus followed by 0.5 μg/kg/hr infusion.

Keywords: Dexmedetomidine, Hysterectomy, Intravenous, Subarachnoid block.

How to cite this article: Nayak PP, Kabade AN, Kelkar VP, Kulkarni SJ. Comparison of the Dosage Regimes of Intravenous Dexmedetomidine to supplement Spinal Anesthesia with Hyperbaric Bupivacaine in Hysterectomy. MGM J Med Sci 2017;4(3):121-124.

Source of support: Nil

Conflict of interest: None