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International Journal of Keratoconus and Ectatic Corneal Diseases


Corneal collagen cross-linking (CXL) is effective in halting progression of keratoconus, nevertheless, it is not without its drawbacks. Water soluble tetrazolium salt (WST) that generates superoxide and hydroxyl radicals following near-infrared (NIR) illumination result in a three-fold increase in corneal stiffness. This seems to be comparable to riboflavin/ultraviolet A (UVA)- mediated cross-linking. Moreover, WST is able to penetrate faster and deep into the cornea while offering protection to endothelial cells and reducing corneal keratocyte loss in the posterior cornea. Early studies suggest good safety and efficacy profile when tested on rabbit eyes in vivo and ex vivo.

Keywords: Corneal collagen cross-linking, Keratoconus, Palladium bacteriochlorin 13’-(2-sulfoethyl) amide dipotassium salt, Water Soluble Tetrazolium Salt-11, Water soluble tetrazolium Salt-11 formulated with dextran T500.

How to cite this article: Abbas S, Barbara R, Barbara A. Water Soluble Tetrazolium Salt-11 as an Alternative to Riboflavin for Corneal Collagen Cross-linking for the Treatment of Keratoconus. Int J Kerat Ect Cor Dis 2017;6(1):42-44.

Source of support: Nil

Conflict of interest: None

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