Aim and objective: We evaluated the effect of preoperative single-dose pregabalin (PG) on postoperative pain in patients undergoing on-pump coronary artery bypass graft (CABG) surgery.

Materials and methods: In this double-blind study, 60 adult patients scheduled for elective on-pump CABG surgery were randomized into two groups of 30 each, viz., PG and placebo (PL). Patients received either oral PG 150 mg or a PL, 1 hour before surgery. All patients received general anesthesia. Postoperative pain relief was provided with intravenous tramadol 50 mg 8 hourly. Postoperative pain was assessed, both at rest and during coughing, with the 10-point verbal rating scale (VRS) at 6, 12, 18, and 24 hours after extubation. Time to extubation, pain scores, requirement of additional analgesics, and adverse effects were compared using chi-square test, unpaired t test, and Mann-Whitney U test.

Results: The time to extubation was significantly prolonged in the PG group compared with PL (9.84 ± 1.88 vs 8.66 ± 2.12 hours, p = 0.027). The mean VRS scores at rest and during coughing were significantly lower in the PG group compared with PL (p < 0.05). However, the requirement of additional analgesics, such as paracetamol or tramadol was similar in the two groups.

Conclusion: A single preoperative oral dose of PG 150 mg was effective in reducing postoperative pain in patients undergoing on-pump CABG compared with a PL.

Keywords: On-pump coronary artery bypass graft, Postoperative pain, Preemptive analgesia, Pregabalin.

How to cite this article: Bhojraj SS, Agaskar RD, Kapila SJ, Patil SK, Behranwala AA. Effect of Single-dose Preoperative Pregabalin on Postoperative Pain after Cardiac Surgery: A Prospective Observational Randomized Double-blind Study. Res Inno in Anesth 2017;2(1):4-8.

Source of support: Nil

Conflict of interest: None