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World Journal of Dentistry


Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Malignant transformation is a major concern related with OSMF. Despite array of studies discussed, pathogenic factors responsible for carcinogenesis in OSMF is still a field of research. Autophagy is a degradation of unwanted cytoplasmic material to maintain cellular biosynthesis when cell is under metabolic stress. Tissue microenvironment consists of diverse mechanisms. It is found that the autophagy has a major impact on these mechanisms to maintain homeostasis. However, dysregulated autophagy has been involved in disruption of the homeostasis and leads to formation of various diseases including cancer. Altered autophagy enhances oxidative stress in the cell which is a critical cause of genetic instability and oncogenesis. Plethora of studies supports that autophagy is implicated in carcinogenesis process and are interlinked with each other. In OSMF, areca nut causes increase in production of reactive oxygen species and formation of oxidative stress which is being wielded by autophagy. Furthermore, modulated autophagy has an impact on senescence and immunity which can lead to cancer. There is an explicit cause and effect relationship present between autophagy and oncogenesis in OSMF. It is our sincere efforts to elucidate this relationship in OSMF so that it can be incorporated in therapeutic purpose at an early stage.

Keywords: Autophagy, Carcinogenesis, Oral submucous fibrosis, Oxidative stress.

How to cite this article: Ganjre AP. Interrelationship of Autophagy and Oxidative Stress in Malignant Transformation of Oral Submucous Fibrosis. World J Dent 2017;8(2):139-144.

Source of support: Nil

Conflict of interest: None

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