Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD), accounting for more than 50% of all deaths. Highsensitivity troponin T (hsTnT) assay is a sensitive and specific marker of myocardial injury and necrosis.
Objective: The objective of this study was to evaluate the prognostic role of elevated hsTnT levels in identifying ESRD patients with high risks of developing cardiovascular morbidity or mortality.
Materials and methods: The present study was a crosssectional observational study conducted in 50 patients fulfilling the prespecified inclusion criteria. Patients were evaluated based on the history, clinical findings, lab investigations including hsTnT, two-dimensional echocardiogram, and duration and frequency of hemodialysis (HD).
Results: The study cohort showed significant correlation of elevated hsTnT levels with left ventricular hypertrophy (p < 0.05), diabetes mellitus (p < 0.005), duration of HD (p < 0.01), and mortality (p < 0.05).
Conclusion: Troponin T is a promising prognostic tool, since elevated levels identify a subset of ESRD patients who have poor survival and higher risk of death. Though sample size was small, this study corroborates previous postulates on this subject. However, being a small sample study, findings could not be subjected to a larger population.
Keywords: Cardiovascular disease, Diabetes, End-stage renal disease, Hemodialysis, High-sensitivity troponin T, Hypertension, Left ventricular hypertrophy.
How to cite this article: Singh AP, Yewale R, Ghanekar J. Cardiac Troponin T as a Prognostic Marker of Cardiovascular Morbidity and Mortality in Patients with End-stage Renal Disease. MGM J Med Sci 2016;3(4):176-180.
Source of support: MGMIHS
Conflict of interest: None