The Bcl-2 (B-cell lymphoma) gene is known through its product, Bcl-2 protein, which protects the cell by blocking postmitotic differentiation from apoptosis. As a critical regulator of apoptosis, Bcl-2 plays an important role in the early stages of oral tumor formation. Because Bcl-2 prevents cell death, its occurrence in odontogenic tissues is helpful in identifying the cell population from which the odontogenic tumors may arise. The aim of this study is to observe the expression of Bcl-2 protein in the different variants of ameloblastomas. In the present study, Bcl-2 expression was observed in 12 different cases of ameloblastomas using a monoclonal antibody against antihuman Bcl-2 oncoprotein. Bcl-2 expression was observed in all the cases of ameloblastomas predominantly in the outer layer, while being negative in the inner cell layer. Based on the study, conclusion has been made that the Bcl-2 protein is thought to play a role in maintaining the stem cell population in the peripheral layers of the tumor nest from which proliferating cells can be recruited.
Keywords: Ameloblastoma, Bcl-2, Immunohistochemistry, Marker, Protein
How to cite this article: Ghanchi M, Jani D. Immunohistochemical Demonstration of Antiapoptotic Proliferating Protein Bcl-2 in the Ameloblastomas. Int J Oral Care Res 2016;4(4):297-300.
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Conflict of interest: None