Introduction: Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family, which is expressed or highly expressed in a variety of solid tumors, including oral cancers.
Aims and objectives: The aim of this study was to evaluate the immunohistochemical (IHC) expression of EGFR in different grades of oral squamous cell carcinoma (OSCC).
Materials and methods: A series of 50 paraffin blocks with different grades of previously diagnosed OSCC were analyzed for EGFR, which was determined by standardised histopathology. A total of 32 (64%) cases out of 50 showed positivity for EGFR.
Results: A total of 32 cases (64%) showed positivity for EGFR, although statistically, a nonsignificant p-value of 0.814 was obtained for EGFR.
Conclusion: We noticed the correlation of increased membrane and cytoplasmic expression of EGFR in poorly differentiated grades of OSCC that can be utilized to predict the prognosis of the patients.
Keywords: Epidermal growth factor receptor, Oral cancer, Squamous cell carcinoma.
How to cite this article: Patil N, Harish H, Sinha S, Shah V, Kariya PB, Sharma U. Immunohistochemical Expression of Epidermal Growth Factor Receptor in Different Grades of Oral Squamous Cell Carcinomas. Int J Oral Care Res 2016;4(4):259-262.
Source of support: Nil
Conflict of interest: None