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International Journal of Oral Care & Research


Introduction: Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family, which is expressed or highly expressed in a variety of solid tumors, including oral cancers.

Aims and objectives: The aim of this study was to evaluate the immunohistochemical (IHC) expression of EGFR in different grades of oral squamous cell carcinoma (OSCC).

Materials and methods: A series of 50 paraffin blocks with different grades of previously diagnosed OSCC were analyzed for EGFR, which was determined by standardised histopathology. A total of 32 (64%) cases out of 50 showed positivity for EGFR.

Results: A total of 32 cases (64%) showed positivity for EGFR, although statistically, a nonsignificant p-value of 0.814 was obtained for EGFR.

Conclusion: We noticed the correlation of increased membrane and cytoplasmic expression of EGFR in poorly differentiated grades of OSCC that can be utilized to predict the prognosis of the patients.

Keywords: Epidermal growth factor receptor, Oral cancer, Squamous cell carcinoma.

How to cite this article: Patil N, Harish H, Sinha S, Shah V, Kariya PB, Sharma U. Immunohistochemical Expression of Epidermal Growth Factor Receptor in Different Grades of Oral Squamous Cell Carcinomas. Int J Oral Care Res 2016;4(4):259-262.

Source of support: Nil

Conflict of interest: None

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