Introduction: Accuracy of intraoperative frozen section diagnosis is very important in ovarian masses as the diagnosis and course of surgery is usually determined by frozen section examination. There is scant data on this topic from this part of the world.
Aims and objectives: To determine accuracy of intraoperative frozen section for appropriate surgical management of ovarian masses and discuss the reasons for discordancy.
Materials and methods: Retrospective analysis of all patients subjected to the exploratory laparotomy for suspected ovarian mass who underwent intraoperative frozen section at Aga Khan University Hospital from January 2006 till December 2014.
Results: Data from 295 patients were analyzed. The mean age was 40.7 years. The final histologic diagnosis revealed benign lesion in 232 (78.6%), borderline in 17 (5.8%), and malignant in 46 (15.6%) cases. The final histologic diagnosis agreed with the frozen section in 288 cases with an accuracy of 97.6%. In seven discordant cases, there were no false positives, and the false negative rate was 2.4%. Sensitivity was highest in the benign and borderline group (100%) and lowest in the malignant group (93.4%), while specificity was highest in malignant (100%) and lowest in the benign group (92%). Tumor size more than 10 cm, borderline, or mucinous histology were significant predictors for discordancy in our study.
Conclusion: Intraoperative frozen section with its high accuracy is a sensitive tool to guide us regarding the surgical management of patients with ovarian masses. This technique is less reliable when we are dealing with large >10 cm masses, mucinous, or borderline tumors.
Keywords: Frozen section, Ovarian neoplasm, Surgery.
How to cite this article: Idrees R, Sheikh Z, Chishti U, Malik TY, Aziz AB, Kayani N. Role of Intraoperative Frozen Section in Surgical Management of Ovarian Masses. J South Asian Feder Menopause Soc 2016;4(2):65-68.
Source of support: Nil
Conflict of interest: None
Date of submission: 04 April 2016
Date of acceptance: 16 June 2016
Date of publication: July 2016