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Journal of Research & Innovation in Anesthesia


Introduction: The addition of neuraxial fentanyl or clonidine potentiates the effect of local anesthetic and increases the duration of action and quality of intraoperative and postoperative analgesia. We decided to conduct this study to analyze the synergistic effect of clonidine and fentanyl with bupivacaine on the duration of analgesia surgies. The primary aim is to determine the duration of analgesia for a combination of intrathecal clonidine and fentanyl with bupivacaine in knee arthroscopic surgeries.

Materials and methods: We included 100 patients undergoing operative arthroscopio procedure and randomly allocated the patients into four different groups of 25 each.

Group S: 15 mg 0.5% hyperbaric bupivacaine with 1.0 mL normal saline (NS).
Group F: 15 mg 0.5% HB with 25 µcg fentanyl citrate and 0.5 mL NS.
Group C: 15 mg 0.5% HB with 75 µcg clonidine and 0.5 mL NS.
Group FC: 15 mg 0.5% HB with 25 µcg fentanyl citrate and 75 µcg clonidine.
All the patients received the spinal dosage of 4 mL.

Results: The duration of spinal analgesia was greatest in group FC (458.4±179.96 minutes, p-value 0.001). The rescue analgesic requirement in 24 hours was significantly less in group FC, and the incidence of side effects was comparable.

Conclusion: The combination of clonidine and fentanyl with bupivacaine intrathecally does augment its sensory, motor, and analgesic action further, and hence it has an additional advantage with similar side effects.

Keywords: Arthroscopic, Bupivacaine, Clonidine fentanyl, Intrathecal, Postoperative analgesia.

How to cite this article: Potdar MP, Kamat LL, Save MP, Jha TR. Effects of Combination of Intrathecal Fentanyl Clonidine with Bupivacaine in Patients for Operative Knee Arthroscopic Procedure. Res Inno in Anesth 2016;1(2):52-57.

Source of support: Nil

Conflict of interest: None.

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